Article

Impaired circadian variation of platelet activity in patients with sleep apnea.

Serveis de Anàlisis Cliniques, Hospital Universitari Son Dureta, C/ Andrea Doria 55, 07014, Palma de Mallorca, Spain.
Sleep And Breathing (impact factor: 1.84). 03/2011; 16(2):355-60. DOI:10.1007/s11325-011-0501-5 pp.355-60
Source: PubMed

ABSTRACT Cardiovascular diseases are frequent in patients with obstructive sleep apnea (OSAS). There is evidence that the day-night pattern of myocardial infarction and sudden cardiac death observed in the general population is altered in patients with OSAS. This study investigates potential abnormalities in the circadian profiles of platelet activity in OSAS.
We studied 37 patients with OSAS [7 of whom were also studied after 3 months on continuous positive airway pressure (CPAP) treatment] and 11 controls. In each subject, we obtained six different blood samples during 24-h period (2200, 0200, 0600, 1000, 1400, and 1800 hours). Platelet activity was determined by flow cytometry immediately after sampling.
We found that nocturnal platelet activity was significantly increased in patients with OSAS (p = 0.043) and that effective treatment with CPAP decreased platelet activity in these patients but differences just failed to reach statistical significance (p = 0.063).
OSAS is associated with increased platelet activity during the night, and that this appears to be improved by chronic use of CPAP. These results may contribute to explain the high prevalence of cardiovascular events during sleep in OSAS.

0 0
 · 
1 Bookmark
 · 
23 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

11 controls
 
3 months
 
37 patients
 
cardiovascular events
 
chronic use
 
circadian profiles
 
continuous positive airway pressure
 
day-night pattern
 
differences
 
different blood samples
 
effective treatment
 
flow cytometry
 
general population
 
myocardial infarction
 
nocturnal platelet activity
 
obstructive
 
OSAS
 
platelet activity
 
study investigates potential abnormalities
 
sudden cardiac death
 

Antonia Barceló