Neonatal screening for hemoglobinopathies.
ABSTRACT A pilot study was undertaken to develop a feasible neonatal screening strategy for hemoglobinopathies. Isoelectric focusing using dried blood spots samples as a primary screening technique was standardized for the first time in India. The screened positives were confirmed by high performance liquid chromatography followed by parental screening, confirmation, and education.
Written by practicing physicians specializing in pediatric
hematology, neonatology, immunology, pediatric infectious
disease, and transfusion medicine, this is a practical guide to
the pathogenesis, recognition, and management of
hematologic problems in the neonate. The focus is on clinical
issues encountered by pediatric specialists. There are chapters
devoted to disorders of leukocytes, platelets, procoagulant and
anticoagulant proteins, and disorders of red blood cells.
Neonatal transfusion, malignant disorders in the newborn,
neonatal hemoglobinopathy screening, and harvesting and
storage of umbilical-cord stem cells are also covered, and
practical approaches to diagnosis and treatment are given.
Pedro de Alarc´ on is a Member of St Jude Children’s Research
Hospital, Professor of Pediatrics at the University of Tennessee.
Eric Werner is Professor of Pediatrics and Director of the
Division of Pediatric Hematology/Oncology at the Eastern
Virginia Medical School and Co-Director of the Division of
Pediatric Hematology/Oncology, Children’s Speciality Group,
Children’s Hospital of the King’s Daughters.
Pedro A. de Alarc´ on
St Jude Children’s Research Hospital
Eric J. Werner
Eastern Virginia Medical School and
Children’s Hospital of the King’s Daughters
Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo
Cambridge University Press
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Published in the United States of America by Cambridge University Press, New York
First published in print format
© Cambridge University Press 2005
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Dedication to Dr Frank A. Oski
Our journey to the creation of this book in neonatal
hematology began with a challenge from Dr Oski to
cian, Dr Oski’s special love was neonatal hematol-
ogy. We both were attracted to Syracuse, New York,
not because of the wonderful weather in that sunny
city of eternal snow but because of the program that
Dr Oski had built both in pediatrics and in pedi-
atric hematology. As Fellows, we had the privilege
and unusual experience of making neonatal hema-
tology rounds once a week. Dr Oski attended in the
search yields 80 publications by Dr Oski in the field
of neonatal hematology. Three editions of Hemato-
logic Problems in the Newborn, co-edited with his
of us maintain an interest in neonatal hematology.
Inspired by Dr Diamond’s contributions, Drs Oski
and Naiman established neonatal hematology as a
field worth devoting a career to. Dr Oski contributed
basic information to the field of neonatal red-cell
a natural sequence of study in an attempt to under-
stand why newborns became “anemic” at birth. The
role of iron, transfusions of red cells, and vitamin E