Article

Relative acidity scale of glycine- and taurine-conjugated bile acids through ESI-MS measurements.

Dipartimento di Chimica, Università di Ferrara, Via Borsari 46, 44100 Ferrara, Italy.
Steroids (impact factor: 2.83). 02/2011; 76(6):596-602. DOI:10.1016/j.steroids.2011.02.028 pp.596-602
Source: PubMed

ABSTRACT The most important bile acids, in the form of glycine and taurine conjugates, have been ordered in terms of relative acidity scale. The measurements have been carried out using mass spectrometric techniques. The group of taurine conjugates confirm the superior acidity over the glycine derivatives. Rationale of the differences found in gas-phase and comparison with the data reported in solution-phase are discussed with the support of theoretical calculations. The study has been completed with the acidity sequence of mixed oxo-hydroxy bile acids.

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Keywords

differences
 
glycine
 
glycine derivatives
 
measurements
 
mixed oxo-hydroxy bile acids
 
relative acidity scale
 
taurine conjugates
 
theoretical calculations