Heteroditopic Binding of Magnetic Resonance Contrast Agents for Increased Relaxivity

A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Suite 2301, Charlestown, MA 02129, USA.
Angewandte Chemie International Edition (Impact Factor: 11.26). 03/2011; 50(11):2621-4. DOI: 10.1002/anie.201007689
Source: PubMed


In die Schranken gewiesen: Bei peptidgerichteten Kontrastmitteln beschränken interne Strukturbewegungen die Relaxivitätsverstärkung. Mithilfe einer fokussierten Bibliothek wurde eine N-terminale Thyminpeptidnukleinsäure (PNA) identifiziert, die eine zusätzliche Bindungstasche im Protein Fibrin erreicht. Die heteroditope Bindung macht das Molekül starr, und die Relaxivität im proteingebundenen Zustand wird erhöht.

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Available from: Zhaoda Zhang, Jun 24, 2015
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