The composition and extent of coronary artery plaque detected by multislice computed tomographic angiography provides incremental prognostic value in patients with suspected coronary artery disease.

Center for Diagnosis, Prevention and Telemedicine, John Paul II Hospital, ul. Prądnicka 80, 31-202 Kraków, Poland.
The international journal of cardiovascular imaging (Impact Factor: 2.32). 03/2011; 28(3):621-31. DOI: 10.1007/s10554-011-9799-0
Source: PubMed

ABSTRACT Multislice computed tomographic coronary angiography (CTCA) provides accurate noninvasive assessment of coronary artery disease (CAD). However, data on the prognostic value of CTCA in patients with suspected CAD are only beginning to emerge. The aim of the study was to assess the prognostic value of CTCA in patients with suspected CAD. Patients (males = 259, females = 235; mean age 58.2 ± 9.8 years) with suspected CAD who underwent 16- or 64-slice CTCA were followed for 1,308 ± 318 days for cardiac death, nonfatal myocaridal infarction (MI) and late (>90 days after CTCA) revascularization. Patient outcomes were related to clinical and CTCA data. Cox proportional-hazards model was applied in stepwise forward fashion to identify outcome predictors. Coronary artery plaque was found in 340 patients. Cardiac events occurred in 40 patients including cardiac death (n = 9), nonfatal MI (n = 8) and late revascularization (n = 23). A multivariable analysis identified the following independent predictors for adverse cardiac events: obstructive plaque in a proximal coronary artery segment (hazard ratio (HR) 2.73; 95% confidence interval (CI): 1.35-5.54; P = 0.005), the number of segments with noncalcified plaque(s) (HR 1.53 per segment; 95%CI: 1.21-1.92; P < 0.001), the number of segments with mixed plaque(s) (HR 1.56 per segment; 95%CI: 1.27-1.92; P < 0.001) and the number of segments with calcified plaque(s) (HR 1.21 per segment; 95%CI: 1.07-1.37; P = 0.002). In patients with suspected CAD, both the extent and composition of atherosclerotic plaque as determined by CTCA are prognostic of subsequent cardiac events.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This study is important for the determination of branches and segments of the first atherosclerotic coronary artery. The objective was to examine the role of epicardial adipose tissue (EAT) volume in estimating the presence and localization of plaque of coronary arteries. Our study is a retrospective study, consisting of 50 male (mean age: 45.5±12 yrs) and 58 female (mean age: 52.5±11.6 yrs). A total of 108 consecutive patients underwent coronary computerized tomography (CT) angiography. Each coronary artery segment was assessed for the presence of atherosclerotic plaque. According to the plaque-involved vessel, patients were grouped as without plaque; plaque-involved left anterior descending artery (LAD), right coronary artery (RCA), or circumflex artery (Cx); and mixed (two or more vessels). The differences in mean values between the two groups were compared using the independent samples t test. Mann-Whitney U test was used for the comparison of continuous variables among groups. While EAT volume was found to be higher in the group with plaque, the difference between the two groups was statistically significant (88.6±9.2 cm3, 67.4±7.2 cm3, respectively, p=0.001). EAT volume was 67.3±7.1 cm3 in the without plaque group, 97.7±22.8 cm3 in LAD, 79.7±10.1 cm3 in RCA, 70.7±8.9 cm3 in Cx, and 101.9±18.6 cm3 in mixed vessels. In the intragroup comparison, the EAT volume of plaque-involved LAD and mixed vessels was significantly higher than in the other groups. The EAT volume of plaque-involved RCA was significantly higher (p=0.015) than in plaque-involved Cx. Increased EAT volume is directly proportional to the presence of coronary artery plaques, especially in LAD and with more than one artery.
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 04/2014; DOI:10.5152/akd.2014.5431 · 0.76 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Coronary computed tomography (CT) angiography has been increasingly used in the diagnosis of coronary artery disease due to improved spatial and temporal resolution with high diagnostic value being reported when compared to invasive coronary angiography. Diagnostic performance of coronary CT angiography has been significantly improved with the technological developments in multislice CT scanners from the early generation of 4-slice CT to the latest 320- slice CT scanners. Despite the promising diagnostic value, coronary CT angiography is still limited in some areas, such as inferior temporal resolution, motion-related artifacts and high false positive results due to severe calcification. The aim of this review is to present an overview of the technical developments of multislice CT and diagnostic value of coronary CT angiography in coronary artery disease based on different generations of multislice CT scanners. Prognostic value of coronary CT angiography in coronary artery disease is also discussed, while limitations and challenges of coronary CT angiography are highlighted.
    World Journal of Cardiology (WJC) 12/2013; 5(12):473-483. DOI:10.4330/wjc.v5.i12.473 · 2.06 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Computed tomography (CT) angiography represents the most important technical development in CT imaging and it has challenged invasive angiography in the diagnostic evaluation of cardiovascular abnormalities. Over the last decades, technological evolution in CT imaging has enabled CT angiography to become a first-line imaging modality in the diagnosis of cardiovascular disease. This review provides an overview of the diagnostic applications of CT angiography (CTA) in cardiovascular disease, with a focus on selected clinical challenges in some common cardiovascular abnormalities, which include abdominal aortic aneurysm (AAA), aortic dissection, pulmonary embolism (PE) and coronary artery disease. An evidence-based review is conducted to demonstrate how CT angiography has changed our approach in the diagnosis and management of cardiovascular disease. Radiation dose reduction strategies are also discussed to show how CT angiography can be performed in a low-dose protocol in the current clinical practice.