Severe insomnia related to high concentrations of raltegravir.

aMedical Pharmacology and Toxicology Department, University Hospital Montpellier I, France bClinical Pharmacy Department, APHP Bichat-Claude Bernard Hospital and EA449 Paris 7 University, Paris, France cInfectious Diseases Department, University Hospital Montpellier I, France.
AIDS (London, England) (Impact Factor: 6.56). 03/2011; 25(5):725-7. DOI: 10.1097/QAD.0b013e32834465c8
Source: PubMed
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    ABSTRACT: Central nervous system (CNS) symptoms have been reported in clinical trials and case reports in patients receiving raltegravir. We investigated CNS symptoms in 453 HIV-infected patients. Of these 47 (10.4%) developed at least one drug related CNS symptom. Predictors of CNS symptoms were concomitant therapy with tenofovir or with proton pump inhibitors which can increase raltegravir concentration. Thus, our data suggest a possible correlation between high raltegravir plasma concentrations and CNS symptoms and therefore their monitoring in clinical practice.
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