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[Wegener's granulomatosis with subglottic stenosis: options for local and systemic treatment. Review of the literature].

Bozena Targońska-Stepniak, Maria Majdan

Katedra i Klinika Reumatologii i Układowych Chorób Tkanki Łacznej Uniwersytetu Medycznego w Lublinie ul. Jaczewskiego 8, 20-950 Lublin.

Journal Article: Annales Academiae Medicae Stetinensis 01/2010; 56 Suppl 1:58-61.

Abstract

Wegener's granulomatosis (WG) is a primary systemic vasculitis with characteristic clinical manifestations from upper airways, lungs, and kidneys. Subglottic stenosis is one of the local symptoms which may occur independently or in association with involvement of other organs.
We present a patient with systemic WG positive for C-ANCA. Regression of pulmonary changes was achieved with induction therapy but the patient developed subglottic stenosis. Endotracheal dilation was partly successful, so systemic treatment had to be reintroduced to inhibit the activity of the disease.
The problem of localized organ lesions in the course of a systemic disease is discussed. It is important to distinguish between signs of active disease requiring systemic therapy and organ lesions which demand a localized approach.

Source: PubMed

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Keywords

characteristic clinical manifestations
 
Endotracheal dilation
 
induction therapy
 
kidneys
 
local symptoms
 
localized approach
 
localized organ lesions
 
lungs
 
organ lesions
 
organs
 
primary systemic vasculitis
 
reintroduced
 
signs
 
Subglottic stenosis
 
systemic WG positive
 
upper airways
 
Wegener's granulomatosis