Article

Effect of kidney disease on glucose handling (including genetic defects).

Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, Lisbon, Portugal.
Kidney international. Supplement 03/2011; DOI:10.1038/ki.2010.510
Source: PubMed

ABSTRACT Reabsorption of glucose in the proximal renal tubule involves the Na(+)-coupled glucose cotransporter (SGLT) and the facilitative glucose transport (GLUT) multigene glucose transport families. Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic disorder characterized by glucosuria in the absence of both hyperglycemia and generalized proximal tubular dysfunction. In this paper we focus on FRG and describe other inherited and acquired clinical conditions associated with glucosuria. In addition, a brief review on the regulation of renal glucose transport in diabetes is provided.

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Keywords

brief review
 
clinical conditions
 
diabetes
 
facilitative glucose transport
 
familial renal glucosuria
 
FRG
 
genetic disorder
 
glucose
 
hyperglycemia
 
Mutations
 
Na(+)-coupled glucose cotransporter
 
Reabsorption
 
renal glucose transport
 
SGLT2 coding gene