Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice

Department of Marine biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Fine arts Avenue, Cochin, 682016 Kerala, India.
Inflammopharmacology 02/2011; 19(6):335-41. DOI: 10.1007/s10787-010-0075-z
Source: PubMed

ABSTRACT Anti-inflammatory effect of the edible mytilid bivalve Perna viridis was evaluated using formalin, carrageenan and dextran-induced paw oedema in mice. The whole mussel tissue without shell was first extracted with ethyl acetate and then successively with methanol and water:ethanol, 7:3 (aqueous/ethanol). Three doses (100, 500 and 1,000 mg/kg) of the extracts (methanol and aqueous/ethanol) were administered orally prior to the injection of inflammatory agents. The inflammation induced by formalin was inhibited by the administration of both extracts for 7 days and the activity was found to be higher for methanol than aqueous/ethanol extract. A dose-dependent reduction in paw thickness was observed for carrageenan-induced paw oedema on treatment with methanol and aqueous/ethanol extracts which was comparable to the standard drug diclofenac. The effect of extracts on dextran-induced oedema was less than that produced by the other two inflammatory stimulants.

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    09/2014; 16(9). DOI:10.5812/ircmj.19259