Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge. Sleep, 34, 335-339

Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
Sleep (Impact Factor: 4.59). 03/2011; 34(3):335-9.
Source: PubMed


To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge.
Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design.
Sleep laboratory.
Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years).
Sleep deprivation.
Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups.
Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly.

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Available from: François Prince, Oct 22, 2014
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    • "These findings have been summarized in reviews utilizing both quantitative [8] [19] [20] [22] [23] and narrative [3,16,17,24–28] approaches. Small-scale experimental studies have shown that short-term sleep deprivation may lead to metabolic dysregulation [29] [30] [31] [32] [33] [34], elevated inflammation [35] [36], and elevated blood pressure (BP) [37]. Whether or not these findings translate to associations with habitual sleep in general population samples remains unclear. "
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    ABSTRACT: Self-reported short or long sleep duration has been associated with adverse cardiometabolic health outcomes in laboratory and epidemiologic studies, but interpretation of such data has been limited by methodologic issues. Adult respondents of the 2007-2008 US National Health and Nutrition Examination Survey (NHANES) were examined in a cross-sectional analysis (N=5649). Self-reported sleep duration was categorized as very short (<5h), short (5-6h), normal (7-8h), or long (⩾9h). Obesity, diabetes mellitus (DM), hypertension, and hyperlipidemia were objectively assessed by self-reported history. Statistical analyses included univariate comparisons across sleep duration categories for all variables. Binary logistic regression analyses and cardiometabolic factor as outcome, with sleep duration category as predictor, were assessed with and without covariates. Observed relationships were further assessed for dependence on race/ethnicity. In adjusted analyses, very short sleep was associated with self-reported hypertension (odds ratio [OR], 2.02, [95% confidence interval {CI},1.45-2.81]; P<0.0001), self-reported hyperlipidemia (OR, 1.96 [95% CI, 1.43-2.69]; P<0.0001), objective hyperlipidemia (OR, 1.41 [95% CI, 1.04-1.91]; P=0.03), self-reported DM (OR, 1.76 [95% CI, 1.13-2.74]; P=0.01), and objective obesity (OR, 1.53 [95% CI, 1.03-1.43]; P=0.005). Regarding short sleep (5-6h), in adjusted analyses, elevated risk was seen for self-reported hypertension (OR, 1.22 [95% CI, 1.02-1.45]; P=0.03) self-reported obesity (OR, 1.21 [95% CI, 1.03-1.43]; P=0.02), and objective obesity (OR, 1.17 [95% CI, 1.00-1.38]; P<0.05). Regarding long sleep (⩾9h), no elevated risk was found for any outcomes. Interactions with race/ethnicity were significant for all outcomes; race/ethnicity differences in patterns of risk varied by outcome studied. In particular, the relationship between very short sleep and obesity was strongest among blacks and the relationship between short sleep and hypertension is strongest among non-Hispanic whites, blacks, and non-Mexican Hispanics/Latinos. Short sleep duration is associated with self-reported and objectively determined adverse cardiometabolic outcomes, even after adjustment for many covariates. Also, these patterns of risk depend on race/ethnicity.
    Sleep Medicine 10/2013; 15(1). DOI:10.1016/j.sleep.2013.09.012 · 3.15 Impact Factor
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    • "We failed to confirm our hypothesis that the reduction in sleep duration would raise the 24-h TG profile, particularly in the overnight period. Sleep restriction has been shown to be associated with increased blood pressure and hypertension (Robillard et al., 2011). In the present study, there was no interaction between sleep duration and day. "
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    ABSTRACT: Short sleep has been associated with cardiovascular risk. The aim of this study was to determine the impact of short-term sleep restriction on lipid profiles and resting blood pressure factors in young, normal-weight individuals (14 men, 13 women). Participants were randomized to five nights of either habitual (9 h) or short (4 h) sleep in a cross-over design separated by a 3-week washout period. There was no sleep × day interaction on lipid profile and blood pressure. Short-term sleep restriction does not alter lipid profiles and resting blood pressure in healthy, normal-weight individuals. The association between short sleep and increased cardiovascular risk reported in the epidemiological literature may be the result of long-term sleep restriction and poor lifestyle choices.
    Journal of Sleep Research 05/2013; 22(6). DOI:10.1111/jsr.12060 · 3.35 Impact Factor
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    • "24 hrs 8 adults increased Ogawa et al. 2003 [42] 24 hrs 6 adults increased Pagani et al. 2009 [43] 24 hrs 24 adults No increase if no other stress Robillard et al. 2011 [44] "
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    ABSTRACT: Hypertension and insomnia are very common and often coexist. There is evidence to suggest that the increasing prevalence of arterial hypertension in the past decade might be related both to an increased prevalence of insomnia and to the decline of sleep duration due to modern lifestyle. The aim of this paper is to reconsider both the clinical evidence of the relationship between conditions of sleep loss and of perceived impairment in sleep quality with hypertension and the potential pathophysiological mechanisms underlying the biological plausibility of their relationship. Through a systematic search from MEDLINE, EMBASE, PsychINFO we selected articles, which reported experimental sleep deprivation designs, or studied sleep duration or insomnia and their relationship with blood pressure or hypertension in participants over 18 years. This analysis shows that experimental sleep deprivation, short sleep duration, and persistent insomnia are associated with increased blood pressure and increased risk of hypertension, even after controlling for others risk factors. Pathophysiological mechanisms underlying this association might be related to inappropriate arousal ("hyperarousal") due to an overactivation of stress system functions. According this hypothesis, prolonged sleep loss or alterations of sleep quality might act as a neurobiological and physiologic stressor that impair brain functions and contribute to allostatic load, compromising stress resilience and somatic health.
    Current pharmaceutical design 11/2012; 19(13). DOI:10.2174/1381612811319130009 · 3.45 Impact Factor
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