Article

The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study.

Bristol Adult Bone Marrow Transplant Unit, University Hospitals Bristol, Bristol, UK.
Bone marrow transplantation (impact factor: 3). 02/2011; 47(1):88-94. DOI:10.1038/bmt.2011.12 pp.88-94
Source: PubMed

ABSTRACT The clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk.

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Keywords

10 months post-SCT
 
19% 4 months post-diagnosis
 
60 patients
 
Actuarial mortality
 
Allo-SCT patients
 
chronic pulmonary disease
 
critically ill
 
greatest risk
 
H1N1 infection
 
H1N1 influenza
 
immunocompetent patients
 
intensive care units
 
median age 42 years
 
patients
 
pneumonia
 
risk factor
 
SCT patients