The relationship between renal functions and thrombolysis in myocardial infarction frame count in patients with slow coronary flow

Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
The Kaohsiung journal of medical sciences (Impact Factor: 0.8). 02/2011; 27(2):55-8. DOI: 10.1016/j.kjms.2010.12.003
Source: PubMed


We investigated the relationship between renal function and coronary thrombolysis in myocardial infarction frame count (TFC) in patients with slow coronary flow (SCF). The patient group was composed of 34 patients with SCF. The control group was made up of 34 well-matched individuals who have normal SCF in their coronary arteries. The coronary flow rates of all subjects were documented by TFC. Glomerular filtration rate (GFR) and corrected GFR (cGFR) were calculated by creatinine clearance according to the Cockcroft-Gault formula. There is no difference in the gender or age of the groups. Blood urea nitrogen and creatinine were significantly higher in the SCF group compared the control group (blood urea nitrogen: 17 ± 6 mg/dL vs. 14 ± 4 mg/dL, p=0.04 and creatine: 0.9 ± 0.1mg/dL vs. 0.7 ± 0.1mg/dL, p=0.01). GFR and cGFR were significantly different between the groups (GFR: 92 ± 28 mL/min vs. 112 ± 27 mL/min, p=0.004 and cGFR: 77 ± 22 mL/min/1.73 m(2)vs. 96 ± 24 mL/min/1.73 m(2), p=0.007). There was a negative correlation between GFR/cGFR and TFC in all coronary arteries. This study shows that impaired renal function is associated with SCF. Patients with SCF have worse renal function compared with patients without SCF.

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    ABSTRACT: Background Slow coronary flow (SCF) is defined as late opacification at the epicardial coronary arteries without stenosis, in this study we search the effect of isolated CSF on P-wave and QT-interval dispersion. Patients and methods Thirty five patients with CSF (group 1), and 30 control subjects (group II) matched in sex and age. Both groups underwent a standard 12-lead surface electrocardiogram. Maximal (P max), minimal P-wave durations (P min), P dispersion (PD), and QT dispersion were measured. All patients underwent selective coronary angiography. Coronary flow rates were documented by Thrombolysis in Myocardial Infarction (TIMI) frame count. Results CSF patients had more P maximum, P dispersion, C QT duration, QT dispersion, and C QT dispersion. TIMl frame counts of CSF patients were significantly higher than those of the control group for all three coronary vessels (P 0.0001). PD was positively correlated with LAD TIMI frame count (r = 0.42; P: 0.01); LCx TIMI frame count (r = 0.40; P: 0.01); and mean TIMI frame count (r = 0.44; P: 0.007), while weak correlated with RCA TIMI frame count (r = 0.22; and not statistically significant P: 0.18), C QT dispersion was positively correlated with LAD TIMI frame count (r = 0.54; P: 0.001); LCx TIMI frame count (r = 0.70; P: 0.001); and mean TIMI frame count (r = 0.50; P: 0.002), while weak correlated with RCA TIMI frame count (r = 0.24; and not statistically significant P: 0.15). Conclusion CSF was found to be associated with prolonged dispersion of P-wave and QT-interval.
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