Article

Endogenous epinephrine protects against obesity induced insulin resistance.

Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0838, United States.
Autonomic neuroscience: basic & clinical (impact factor: 1.82). 02/2011; 162(1-2):32-4. DOI:10.1016/j.autneu.2011.01.009 pp.32-4
Source: PubMed

ABSTRACT Epinephrine (E) is a hormone released from the adrenal medulla in response to low blood sugar and other stresses. E and related β2-adrenergic agonists are used to treat asthma, but a side effect is high blood sugar. C57BL/6 mice prone to overfeeding induced type II diabetes had the PNMT gene knocked out to prevent E synthesis. These E deficient mice were very similar to control animals on a 14% fat diet. On a 40.6% fat diet they gained 20 to 33% more weight than control animals and increased their blood glucose response to a glucose tolerance test because they became resistant to insulin. Although the short term effect of β2-agonists such as E is to raise blood glucose, some long acting β2-agonists improve muscle glucose uptake. Endogenous E protects against overfeeding induced diabetes. Since adrenal E release can be impaired with aging and diabetes, endogenous E may help prevent adult onset diabetes.

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Keywords

acting β2-agonists
 
adrenal E release
 
adrenal medulla
 
adult onset diabetes
 
blood glucose
 
blood glucose response
 
C57BL/6 mice prone
 
E deficient mice
 
Epinephrine
 
insulin
 
low blood sugar
 
muscle glucose uptake
 
overfeeding induced diabetes
 
overfeeding induced type II diabetes
 
PNMT gene
 
side effect
 
β2-agonists