Development of Cu2O/Carbon Vulcan XC-72 as non-enzymatic sensor for glucose determination.

Chemical Engineering Department, National Research Center, Dokki, Giza, Egypt.
Biosensors & Bioelectronics (Impact Factor: 6.45). 02/2011; 26(8):3542-8. DOI: 10.1016/j.bios.2011.01.042
Source: PubMed

ABSTRACT A novel and stable non-enzymatic glucose sensor was developed based on the chemical reduction of Cu(2)O nanoparticles on Carbon Vulcan XC-72 using NaBH(4) as the reducing agent via the impregnation method. Different molar ratios of NaBH(4) to the copper salt were employed during the reduction step. This was found to affect the morphology; composition and structure of the prepared samples as investigated by TEM, EDX and XRD analyses. Cyclic voltammetry and chronoamperometry were applied to examine the electrocatalytic activity of the different samples of Cu(2)O/Carbon Vulcan XC-72 towards glucose oxidation in alkaline medium. The 'x70' sample got the highest oxidation current density and the lowest oxidation potential. The performance of this sensor was evaluated showing a wide linear range up to 6mM with sensitivity of 629 μA cm(-2)mM(-1) and detection limit of 2.4 μM. Its good tolerance to ascorbic acid with long-term stability elects Cu(2)O/Carbon Vulcan XC-72 as a promising glucose sensor.

  • [Show abstract] [Hide abstract]
    ABSTRACT: A new type of cobalt nanoparticles modified indium tin oxide electrode (CoNPs/ITO) was fabricated using ion implantation technique. This method is low-cost, facile and environmentally friendly without the use of any other chemicals. Electrochemical oxidation of glucose with this sensor was examined by cyclic voltammetry (CV) and chronoamperometry in alkaline aqueous solutions. The proposed sensor exhibited prominent electrocatalytic activity toward the oxidation of glucose with a low limit of detection of 0.25 µM. Furthermore, the fabricated electrode showed excellent selectivity, good reproducibility and long-term stability. Thus CoNPs/ITO electrode is a promising candidate in the development of non-enzymatic glucose sensors.
    Electroanalysis 12/2014; 26(12). DOI:10.1002/elan.201400347 · 2.50 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The Ni0.31Co0.69S2 nanoparticle/reduced graphene oxide (Ni0.31Co0.69S2/rGO) composites have been synthesized via hydrothermal method and then applied as the active materials for high performance non-enzymatic glucose sensor. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) were employed to characterize the morphology of the as-prepared samples. The results revealed that the abundant nanoparticles with the size of about 150 nm uniformly anchored on the reduced graphene oxide nanosheets which are interconnected to form porous graphene framework. The subsequent electrochemical measurements and kinetic analysis showed that the Ni0.33Co0.67S2/rGO composites possessed the excellent electrocatalytic activity to glucose oxidation with a low detection limit of 0.078 μM and wide linear range of 0.001-5 mM and 5-16 mM. And the sensitivities for two liner ranges are 1753 μA mM-1 cm-2 and 954.7 μA mM-1 cm-2, respectively. Additionally, the favorable selectivity, long-term stability and superior practical application were also obtained. All these results indicate the Ni0.33Co0.67S2/rGO composites are a promising active material for non-enzymatic glucose sensors.
    01/2015; 3(9). DOI:10.1039/C4TA06553K
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: CuO nanofibers (NFs) were fabricated via the traditional electrospinning technique and subsequent thermal treatment processes. Using CuO NFs as precursors and glucose as a reducing agent, CuO/Cu2O NFs, with high surface areas and ultralong one dimensional (1D) nanostructures, were obtained by a partial reduction of CuO NFs. Comparing with pure CuO NFs, CuO/Cu2O NFs, as non-enzymatic electrode materials, showed a much higher sensitivity of 830 μA mM−1 cm−2 and a much wider detection range from 0.5 mM to 10 mM for the amperometric detection of glucose. The excellent electrocatalytic performances could be ascribed to the following advantages: (1) the CuO/Cu2O NFs with Cu(II)/Cu(I) multiple oxidation states system could promote the redox reactions between electrode materials and glucose, and the reactive sites became more active due to the synergic effect; (2) the surface of CuO/Cu2O NFs became smoother after partial reduction, resulting in less adsorption of the intermediates during the oxidation of glucose, generating the enlarged detection range. Therefore, the CuO/Cu2O composite NFs electrode materials, with a multiple oxidation states system, would be promising candidates for the development of non-enzymatic glucose sensors.
    RSC Advances 01/2014; 4(59):31056. DOI:10.1039/C4RA03258F · 3.71 Impact Factor


1 Download
Available from
Jan 15, 2015