Development of Cu2O/Carbon Vulcan XC-72 as non-enzymatic sensor for glucose determination.
ABSTRACT A novel and stable non-enzymatic glucose sensor was developed based on the chemical reduction of Cu(2)O nanoparticles on Carbon Vulcan XC-72 using NaBH(4) as the reducing agent via the impregnation method. Different molar ratios of NaBH(4) to the copper salt were employed during the reduction step. This was found to affect the morphology; composition and structure of the prepared samples as investigated by TEM, EDX and XRD analyses. Cyclic voltammetry and chronoamperometry were applied to examine the electrocatalytic activity of the different samples of Cu(2)O/Carbon Vulcan XC-72 towards glucose oxidation in alkaline medium. The 'x70' sample got the highest oxidation current density and the lowest oxidation potential. The performance of this sensor was evaluated showing a wide linear range up to 6mM with sensitivity of 629 μA cm(-2)mM(-1) and detection limit of 2.4 μM. Its good tolerance to ascorbic acid with long-term stability elects Cu(2)O/Carbon Vulcan XC-72 as a promising glucose sensor.
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ABSTRACT: Currently, there is an overwhelming demand for the development and improvement of glucose sensors. Not only has the number of people requiring these sensors significantly increased over the last decade, so has the demand to make sensors which are both biocompatible and have increased sensing capabilities as compared to current technologies. In order to meet these needs, a move towards nonenzymatic glucose sensors has begun. These new sensors have garnered significant interest due to their capacity to achieve continuous glucose monitoring, their high stability compared to traditional glucose sensors, and the ease of their fabrication. Research has been extensively geared towards the preparation of these nonenzymatic glucose sensors from novel materials, often with unique micro- or nano-structures, which possess ideal properties for electrochemical biosensor applications. In recent years, a variety of materials including noble metals, metal oxides, carbon nanotubes, graphene, polymers, and composites have been explored for their electrocatalytic response to the oxidation of glucose. In this review, the most recent advances in nonenzymatic glucose sensors are visited, with the focus being on the last five years of research.Materials science & engineering. C, Materials for biological applications. 08/2014; 41C:100-118.
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ABSTRACT: A helical TiO2 nanotube (TNT) array modified with cuprous oxide (Cu2O) electrode was fabricated and used for nonenzymatic glucose detection. The structure and morphology of Cu2O/TNT were characterized by X-ray diffraction and transmission electron microscopy. The electrocatalytic performance of Cu2O/TNT electrode for glucose oxidation was investigated by cyclic voltammetry and chronoamperometry. At an applied potential of +0.65V versus SCE, a linear range was obtained within the concentration range of 3.0-9.0mM with a detection limit of 62μM (signal/noise=3). The response time was approximately 3s after adding 0.10mM glucose. Formate and gluconic acid were identified as the main products of the glucose oxidation using (1)H NMR spectrometry. A possible mechanism for continuous glucose oxidation was also proposed.Biosensors & bioelectronics 03/2014; 59C:243-250. · 5.43 Impact Factor
- Sensors and Actuators B Chemical 11/2014; · 3.84 Impact Factor