Association of catechol-O-methyl transferase (COMT) gene −287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population
ABSTRACT Several studies suggested a genetic component in the etiology of obsessive-compulsive disorder (OCD). COMT involves in the degradation of dopamine and norepinephrin. As another functional SNP locus, COMT -287A/G polymorphism showed an effect on enzyme activity, suggesting that it may influence brain dopamine levels. To identify association of COMT -287A/G polymorphism with susceptibility to OCD in Chinese Han population. We evaluate the genetic contribution of the COMT -287A/G polymorphism in 200 OCD patients and 403 OCD-free control of Chinese Han population by PCR-RFLP. In addition, we investigate whether COMT -287A/G polymorphism is associated with one or more of these symptom dimensions or other characteristics such as sex, age of onset, and tic-relatedness and evaluate the association of the factorial structure of OCD symptoms from the Y-BOCS checklist with the COMT -287A/G polymorphism. A statistical difference was found in the genotypic frequencies of COMT -287A/G between the OCD and control groups (χ(2) = 13.99, DF = 2, P = 0.00091) and in the genotypic frequencies of GG genotype versus AA and AG genotypes of COMT -287 (χ(2) = 13.49, DF = 1, P = 0.00024, OR = 3.43, 95% CI = 1.78-6.62). There was a trend for an association in the genotypic distributions of COMT -287A/G polymorphism of males (χ(2) = 27.81; DF = 2; P < 0.001) and females (χ(2) = 7.31; DF = 2; P = 0.026) between the OCD patients and the controls. Using principal component analysis, we derived 5 factors from 12 main contents of OCD symptoms from the Y-BOCS checklist and found no association with COMT -287A/G polymorphism. Our study supports the involvement of the COMT -287A/G polymorphism in the genetic susceptibility to OCD in Chinese Han population.
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ABSTRACT: To identify the association of Catechol-O-methyl transferase (COMT) -287A/G polymorphism with susceptibility to TS in Chinese Han population. We evaluated the genetic contribution of the COMT -287A/G polymorphism in 108 TS patients including all their parents in Chinese Han population using transmission disequilibrium test and haplotype relative risk design. Our results revealed that no significant association was found in COMT -287A/G genotypic and allelic frequencies with TS. Our results also suggested that there may be a lack of association between the TS and -287A/G polymorphism of COMT in Chinese Han population.European Child & Adolescent Psychiatry 12/2011; 20(11-12):593-6. DOI:10.1007/s00787-011-0226-9 · 3.55 Impact Factor
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ABSTRACT: Schizophrenia is a complex disease caused by genetic and environmental factors with a global heritability of more than 80%. By the end of the 1970s, Chinese scientists reported a heritability of schizophrenia of 82.9% in the Chinese Han population. Continuous improvements in research techniques and the recruitment of larger samples have made it possible for Chinese scientists to identify a number of candidate susceptibility genes for schizophrenia. This article reviews the results in genetic research of schizophrenia by Chinese scientists over the last five decades.08/2012; 24(4):187-99. DOI:10.3969/j.issn.1002-0829.2012.04.001