Article

The relationship of prions and translation.

Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, USA.
WIREs RNA 01/2010; 1(1):81-9. DOI:10.1002/wrna.8 pp.81-9
Source: PubMed

ABSTRACT Prions are infectious proteins, without the need for an accompanying nucleic acid. Nonetheless, there are connections of prions with translation and RNA, which we explore here. Most prions are based on self-propagating amyloids. The yeast [PSI+] prion is an amyloid of Sup35p, a subunit of the translation termination factor. The normal function of the Sup35p prion domain is in shortening the 3 polyA of mRNAs and thus in mRNA turnover. The [ISP+] prion is so named because it produces antisuppression, the opposite of the effect of [PSI+]. Another connection of prions with translation is the influence on prion propagation and generation of ribosome-associated chaperones, the Ssbs, and a chaperone activity intrinsic to the 60S ribosomal subunits.

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Keywords

3 polyA
 
60S ribosomal subunits
 
accompanying nucleic acid
 
amyloid
 
chaperone activity intrinsic
 
mRNA turnover
 
normal function
 
prion propagation
 
prions
 
ribosome-associated chaperones
 
self-propagating amyloids
 
Sup35p prion domain
 
translation termination factor
 
yeast [PSI+] prion