Article

The embryologic basis for the anatomy of the cerebral vasculature related to arteriovenous malformations.

Australian School of Advanced Medicine, Macquarie University, 2 Technology Place, Sydney, New South Wales 2109, Australia.
Journal of Clinical Neuroscience (Impact Factor: 1.25). 02/2011; 18(4):464-9. DOI: 10.1016/j.jocn.2010.12.004
Source: PubMed

ABSTRACT A detailed understanding of vascular anatomy is essential to facilitate appropriate decision-making by clinicians responsible for treating arteriovenous malformations (AVM) of the brain and dura. This work reviews the embryologic development of the cerebral vasculature, including the dural venous sinuses, with a focus on the relevant angioarchitecture. There is little doubt that dural AVM are acquired lesions; however, conflicting evidence exists regarding the pathophysiology of brain AVM. Patients described in this review provide support for both of the proposed mechanisms for the development of brain AVM (post-natal development compared to embryologic origin). Further work is required to improve our understanding of the pathophysiology of these lesions.

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