Tremor-Some Controversial Aspects

Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom.
Movement Disorders (Impact Factor: 5.63). 01/2011; 26(1):18-23. DOI: 10.1002/mds.23289
Source: PubMed

ABSTRACT The commonest cause of pathological tremor is essential tremor (ET). However, it has proved difficult to identify genetic mutations causing ET, particularly because other causes of tremor continue to be misdiagnosed as ET. Whether subjects with dystonia or Parkinson's disease (PD) carry an increased genetic risk of developing ET, or vice versa, is controversial. In addition, the notion of a separate disorder of benign tremulous parkinsonism (BTP) has been debated. This article gives a selective viewpoint on some areas of uncertainty and controversy in tremor.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The most frequently seen types of tremor are essential (ET) and parkinsonian tremor (PT) and in some patients clinical characteristics of these tremor types overlap. It is vital to distinguish between these two types of tremor in order to reach the right diagnosis and select the appropriate treatment. One of the widely used methods for tremor detection and discrimination, appropriate for a quick ambulatory assessment of the patient's tremor, is spirography. With spirography, the tremor can be observed through several parameters, for example, tremor spectrum and spiral image, which give useful information for its identification. Standard spirography parameters of ET and PT can overlap; therefore, these parameters are often not enough for identification of the observed tremor. To increase the specificity and sensitivity of spirography for PT, ET and normal, tremor free controls, we used the wavelet analysis with Morlet wavelet transform. To facilitate analysis, comparison, storage, and retrieval of spirography tremor records we also developed an integrated computer assisted spirography system that increases the convenience of outpatient tremor identification and follow-up. We conclude that wavelet analysis of spirography records increases the sensitivity and specificity of the method, thus, facilitating the distinction between ET and PT.
    BioMed Research International 08/2014; 2014:934746. DOI:10.1155/2014/934746 · 2.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The features of the tremor in essential tremor are often not fully appreciated, and essential tremor is frequently mis-diagnosed. Close inspection indicates that the tremor is characterized by a specific and definable pattern of features. Recognizing these features will aid in the diagnosis. The features are as follows: (1) kinetic tremor is greater than postural tremor, for postural tremor, (2) wrist tremor is greater than metacarpal joint tremor and wrist flexion-extension tremor is greater than wrist rotation tremor, (3) tremor is regularly recurrent and without directionality, (4) arm tremor is generally mildly asymmetric, (5) postural tremors (right, left) are out of phase, (6) on spiral drawing, a single tremor orientation axis is often identifiable, (7) intention tremor (finger-nose-finger) occurs in 50% of cases, (8) rest tremor (in the arms but not the legs) can occur as a late feature, (9) arm tremor precedes head tremor, and head tremor occurs mainly in women, (10) head tremor, unless severe, resolves while supine, (11) patients are often unaware of head tremor, (12) tremor is progressive.
    Expert Review of Neurotherapeutics 08/2014; 14(9):1-9. DOI:10.1586/14737175.2014.936389 · 2.83 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To test the hypothesis that adult-onset primary dystonia may be the underlying etiology of tremulous patients with clinical diagnosis of Parkinson disease (PD) but without evidence of dopaminergic deficit at nigrostriatal SPECT imaging.
    Neurology 08/2014; DOI:10.1212/WNL.0000000000000821 · 8.30 Impact Factor

Full-text (2 Sources)

Available from
May 20, 2014