Article

Application of terahertz absorption spectroscopy to evaluation of aging variation of medicine.

Nagahama Institute of Bio-science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan.
Analytical Sciences (impact factor: 1.25). 01/2011; 27(2):209-12. pp.209-12
Source: PubMed

ABSTRACT The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD(®) (5 mg), Basen OD(®) (0.2 mg) and Gaster D(®) (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

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Keywords

absorption spectra
 
Amlodin OD(®)
 
differences
 
diluting agents
 
effective compounds
 
expiration date
 
expiration dates
 
intermolecular interaction
 
kinds
 
main effective compound
 
modifications
 
polymorph
 
terahertz time domain spectroscopy
 
THz absorption spectra
 
THz spectra
 
X-Ray powder diffraction