Mindfulness-based stress reduction for patients with anxiety disorders: evaluation in a randomized controlled trial. Behaviour Research and Therapy, 30(4), 281-288

Department of Clinical Psychology, University of Bergen, Christiesgate 12, 5015 Bergen, Norway.
Behaviour Research and Therapy (Impact Factor: 3.85). 04/2011; 49(4):281-8. DOI: 10.1016/j.brat.2011.01.007
Source: PubMed


The aim of this study was to investigate the effect of mindfulness-based stress reduction (MBSR) for patients with heterogeneous anxiety disorders. Seventy-six self-referred patients were randomized to MBSR or a waiting-list control condition. Eight participants did not complete the eight-week MBSR intervention. Treatment completers improved significantly on all outcome measures compared to controls. The completer sample showed medium to large effect sizes on measures of anxiety (Cohen's d = 0.55-0.97), and a large effect size for symptoms of depression (Cohen's d = 0.97). Intention-to-treat analyses yielded effect sizes in the small to moderate range (Cohen's d = 0.32-0.76). Gains were maintained at six months follow-up. The percentage of participants reaching recovered status was highest for symptom measures of depression and anxiety, and lower for worry and trait anxiety. Mediation analyses indicated that mindfulness fully mediated changes in acute anxiety symptoms, and partially mediated changes in worry and trait anxiety. However, the present study did not find evidence of temporal precedence for the proposed mediator. In the absence of true mediation and an active control condition, it cannot be ruled out that results are due to non-specific aspects of treatment. Despite these and other limitations, we conclude that MBSR is an effective treatment for anxiety disorders and related symptomatology.

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    • "Such conditions include depression, anxiety disorders, insomnia, stress, and chronic pain (Chiesa and Serretti 2011; Gross et al. 2011; Irving et al. 2009; Klainin-Yobas et al. 2012; Morone et al. 2008; Rosenzweig et al. 2010). For example, empirical evidence suggests that mindfulness-based interventions are highly effective in reducing symptoms of depression and anxiety and have long-term benefits for preventing relapse in adults with psychiatric disorders (Klainin-Yobas et al. 2012; Vollestad et al. 2011). Furthermore, greater estimates of efficacy were associated with increased duration of the intervention sessions and more mindfulness meditation practice (Klainin-Yobas et al. 2012). "

    Mindfulness 11/2015; DOI:10.1007/s12671-015-0457-9
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    • "These authors also cited the need for additional randomized, longitudinal studies. In other clinical populations, evidence suggested that MBSR improved menopausal symptoms, insomnia, anxiety, subjective well-being, empathy, perceived daily stressors, and other mental health indicators, and it decreased pain associated with fibromyalgia and failed back surgery (Brown, West, Loverich, & Biegel, 2011; Carmody et al., 2011; Esmer, Blum, Rulf, & Pier, 2010; Gross et al., 2011; Kerrigan et al., 2011; Khoury et al., 2013; Schmidt et al., 2011; Shapiro, Brown, Thoresen, & Plante, 2011; Vollestad, Sivertsen, & Nielsen, 2011). "
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    • "These alternatives need not be mutually exclusive. Nevertheless, available evidence supports a direction of causality from mindfulness to lower emotional distress, since research has shown that mindfulness-based interventions have a positive influence on anxiety and depressive symptoms (Hofmann et al., 2010) and that these effects are (partly) mediated by an increase in levels of mindfulness (Bränström et al., 2010; Nyklíček et al., 2014; Nyklíček & Kuijpers, 2008; Vøllestad et al., 2011). In addition, one recent study that measured weekly change in mindfulness during a mindfulness intervention showed that an increase in mindfulness preceded the reduction of perceived stress (Baer et al., 2012). "
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