Article

Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Journal of Clinical Neuroscience (impact factor: 1.25). 02/2011; 18(4):549-53. DOI:10.1016/j.jocn.2010.08.025 pp.549-53
Source: PubMed

ABSTRACT Human brain arteriovenous malformation (BAVM) tissue contains increased levels of vascular endothelial growth factor A (VEGFA). We carried out a case-control study to determine whether polymorphisms in the VEGFA gene are associated with sporadic BAVM. Nine selected VEGFA single-nucleotide polymorphisms (SNP) were genotyped in 319 patients with BAVM and 333 controls from a Chinese population using the MassARRAY genotyping system. We found four single variants in the VEGFA gene (rs1547651, rs2010963, rs833069 and rs3025010), with one haplotype, ACT, possibly associated with the risk of developing BAVM.

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Keywords

case-control study
 
Chinese population
 
Human brain arteriovenous malformation
 
MassARRAY genotyping system
 
single variants
 
SNP
 
sporadic BAVM
 
vascular endothelial growth factor
 
VEGFA
 
VEGFA gene
 
VEGFA single-nucleotide polymorphisms