Article

Tumor disease and associated congenital abnormalities on prenatal MRI.

Department of Radiology, Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
European journal of radiology (impact factor: 2.65). 02/2011; 81(2):e115-22. DOI:10.1016/j.ejrad.2010.12.095 pp.e115-22
Source: PubMed

ABSTRACT Fetal tumors can have a devastating effect on the fetus, and may occur in association with congenital malformations. In view of the increasing role of fetal magnetic resonance imaging (MRI) as an adjunct to prenatal ultrasonography (US), we sought to demonstrate the visualization of fetal tumors, with regard to congenital abnormalities, on MRI.
This retrospective study included 18 fetuses with tumors depicted on fetal MRI after suspicious US findings. An MRI standard protocol was used to diagnose tumors judged as benign or malignant. All organ systems were assessed for tumor-related complications and other congenital malformations. Available US results and histopathology were compared with MRI.
There were 13/18 (72.2%) benign and 5/18 (27.8%) malignant tumors diagnosed: a cerebral primitive neuroectodermal tumor in 1/18, head-neck teratomas in 4/18; ventricular rhabdomyomas in 4/18; a cardiac teratoma in 1/18; a hepatoblastoma in 1/18; neuroblastomas in 2/18; a cystic hemorrhagic adrenal hyperplasia in 1/18; a pelvic leiomyoma in 1/18; sacrococcygeal teratomas in 3/18. Tumor-related complications were present in 13/18 (72.2%) cases; other congenital abnormalities in 3/18 (16.7%). MRI diagnosis and histology were concordant in 8/11 (72.7%) cases. In 6/12 (50%) cases, US and MRI diagnoses were concordant, and, in 6/12 (50%) cases, additional MRI findings changed the US diagnosis.
Our MRI results demonstrate the visualization of fetal tumors, with frequently encountered tumor-related complications, and other exceptional congenital abnormalities, which may provide important information for perinatal management. Compared to prenatal US, MRI may add important findings in certain cases.

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Keywords

additional MRI findings
 
cerebral primitive neuroectodermal tumor
 
cystic hemorrhagic adrenal hyperplasia
 
devastating effect
 
diagnose tumors judged
 
fetal magnetic resonance imaging
 
fetal MRI
 
fetal tumors
 
histopathology
 
MRI diagnoses
 
MRI results
 
MRI standard protocol
 
pelvic leiomyoma
 
prenatal ultrasonography
 
retrospective study
 
sacrococcygeal teratomas
 
Tumor-related complications
 
tumors
 
ventricular rhabdomyomas
 
visualization