One NOTCH Further: Jagged 1 in Bone Metastasis

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Cancer cell (Impact Factor: 23.89). 02/2011; 19(2):159-61. DOI: 10.1016/j.ccr.2011.01.043
Source: PubMed

ABSTRACT The outgrowth of metastatic cells to bone depends on the interaction between multiple intrinsic and host factors. In this issue of Cancer Cell, Sethi and colleagues report Notch signaling in bone cells as responsible for promoting this outgrowth and provide evidence for a beneficial treatment effect of NOTCH inhibitors.

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