The Short QT Syndrome Proposed Diagnostic Criteria.

Inherited Arrhythmia Clinic and Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Journal of the American College of Cardiology (Impact Factor: 15.34). 02/2011; 57(7):802-12. DOI: 10.1016/j.jacc.2010.09.048
Source: PubMed

ABSTRACT We aimed to develop diagnostic criteria for the short QT syndrome (SQTS) to facilitate clinical evaluation of suspected cases.
The SQTS is a cardiac channelopathy associated with atrial fibrillation and sudden cardiac death. Ten years after its original description, a consensus regarding an appropriate QT interval cutoff and specific diagnostic criteria have yet to be established.
The MEDLINE database was searched for all reported cases of SQTS in the English language, and all relevant data were extracted. The distribution of QT intervals and electrocardiographic (ECG) features in affected cases were analyzed and compared to data derived from ECG analysis from general population studies.
A total of 61 reported cases of SQTS were identified. Index events, including sudden cardiac death, aborted cardiac arrest, syncope, and/or atrial fibrillation occurred in 35 of 61 (57.4%) cases. The cohort was predominantly male (75.4%) and had a mean QT(c) value of 306.7 ms with values ranging from 248 to 381 ms in symptomatic cases. In reference to the ECG characteristics of the general population, and in consideration of clinical presentation, family history, and genetic findings, a highly sensitive diagnostic scoring system was developed.
Based on a comprehensive review of 61 reported cases of the SQTS, formal diagnostic criteria have been proposed that will facilitate diagnostic evaluation in suspected cases of SQTS. Diagnostic criteria may lead to a greater recognition of this condition and provoke screening of at-risk family members.

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Available from: Jason D Roberts, Nov 24, 2014
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    • "In 2011 Gollob et all defined the clinical criteria for the diagnosis of SQTS. The authors considered 61 patients and made a score using data from these patients (Table 3)[16]. There is not a widely accepted cut-off for QTc, but generally these patients present a QT interval shorter than 320 ms. "
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    • "The lower grey zone of the QTc interval duration is less clear than the upper one, rendering the diagnosis of SQTS more complex. A probabilistic model with a sum score ranging from a " low " to " high " probability of SQTS was recently proposed by Gollob et al. (2011b) to assist in the diagnosis. Their model, however, requires further validation from independent sources. "
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