Binge Eating in Parkinson's Disease: Prevalence, Correlates and the Contribution of Deep Brain Stimulation

Dept. of Clinical & Health Psychology, University of Florida in Gainesville, FL, USA.
The Journal of Neuropsychiatry and Clinical Neurosciences (Impact Factor: 2.82). 02/2011; 23(1):56-62. DOI: 10.1176/appi.neuropsych.23.1.56
Source: PubMed


Of 96 Parkinson's disease patients surveyed at the University of Florida Movement Disorders Center, one (1%) met diagnostic criteria for binge-eating disorder. Eight (8.3%) exhibited subthreshold binge eating. Psychometric criteria classified problem gambling in 17.8%, hoarding in 8.3%, compulsive buying in 11.5%, hypersexuality in 1.0%, and mania in 1.0% of patients. More overeaters met psychometric criteria for at least one additional impulse-control disorder (67% versus 29%). No more overeaters than non-overeaters were taking a dopamine agonist (44% versus 41%). More overeaters had a history of subthalamic deep brain stimulation (DBS; 44% versus 14%). History of DBS was the only independent predictor of overeating.

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    • "The consequence is that we can only speculate here about the effects of STN-DBS on non-motor clinical disorders. Several non-motor manifestations of STN- DBS in PD patients have been described, including manic states and addictive behaviors (Funkiewiez et al., 2003; Kulisevsky et al., 2002; Mallet et al., 2007; Ulla et al., 2011; Zahodne et al., 2011). Regarding apathy, there is a debate about whether it is improved or aggravated by STN-DBS, which is confused by the fact that dopaminergic medication is usually reduced after electrode implantation (Chaudhuri and Schapira, 2009; Czernecki et al., 2008; Kirsch-Darrow et al., 2011; Le Jeune et al., 2009; Thobois et al., 2010). "
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    • "Although numerous publications report weight gain, the motivational state of these patients has been rarely studied to favor instead metabolic or motor explanation. Interestingly, a recent report studying bingeeating in PD patients has highlighted the fact that the over-eaters were indeed those patients subjected to STN DBS (Zahodne et al., 2011). "
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