Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women.
ABSTRACT The aim of this study was to investigate retinol-binding protein-4 (RBP4) levels in maternal and umbilical cord serum in patients in the third trimester of pregnancy with preeclampsia in comparison to levels in normal pregnant women.
The RBP4 levels in maternal and umbilical cord serum were measured and compared by enzyme-linked immunosorbent assay in 16 normal pregnant and 16 patients with preeclampsia.
Both maternal and umbilical cord serum RBP4 levels were significantly decreased in patients with preeclampsia, as compared to normal pregnant women (maternal serum, median 168.0 μg/mL vs. 202.0 μg/mL, P<0.001; umbilical cord serum, median 147.9 μg/mL vs. 193.0 μg/mL, P<0.001). Preeclampsia was independently related to RBP4 levels of maternal and umbilical cord serum.
Both maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy.
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ABSTRACT: The present study examined the expression and occurrence of different retinoid binding proteins in human first trimester and term placenta. At both stages, messenger RNA for the serum transport vehicle for retinol, retinol-binding protein (RBP), was detected only in decidual cells of the basal plate. In contrast, immunoreactive RBP (irRBP) was present in syncytiotrophoblast, core mesenchyme and lumen of vessels in placental villi and in mesenchyme and decidual cells of the basal plate. In villi of term placentae, however, staining for irRBP was lost in syncytiotrophoblasts and villous core mesenchyme. A putative placental RBP-receptor, approx 60-65kDa, was detected in the villous syncytiotrophoblast of both stages investigated. Immunoreactivity for the cellular retinol binding protein type I (CRBP I), was found in villous stromal cells and in decidual cells of the basal plate in sections of first trimester and term placenta. These results may suggest that maternal RBP-retinol is transferred across the chorionic villi to the fetal/villous circulation and that villous absorption of the complex is mediated via a placental RBP-receptor. Moreover, binding and possibly also metabolism of retinol may occur in the CRBP I positive villous stromal cells and decidual cells of the basal plate. In the latter, release of placental RBP-retinol may also be anticipated.Placenta 01/1999; 20(5-6):459-65. · 3.12 Impact Factor