Regulation of fatty acid metabolism by cell autonomous circadian clocks: time to fatten up on information?

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Journal of Biological Chemistry (Impact Factor: 4.6). 02/2011; 286(14):11883-9. DOI: 10.1074/jbc.R110.214643
Source: PubMed

ABSTRACT Molecular, cellular, and animal-based studies have recently exposed circadian clocks as critical regulators of energy balance. Invariably, mouse models of genetically manipulated circadian clock components display features indicative of altered lipid/fatty acid metabolism, including differential adiposity and circulating lipids. The purpose of this minireview is to provide a comprehensive summary of current knowledge regarding the regulation of fatty acid metabolism by distinct cell autonomous circadian clocks. The implications of these recent findings for cardiometabolic disease and human health are discussed.

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    • "In addition, changes in catabolic and anabolic pathways were reported to alter liver metabolome and improve nutrient utilization and energy expenditure (Hatori et al., 2012). However, circadian clocks located in the liver and other organs and tissues rule out a series of physiological functions including those relating to lipid metabolism (Asher & Schibler, 2011; Bass & Takahashi, 2010; Bray & Young, 2011; Eckel-Mahan et al., 2012), in all likelihood regardless of food availability, although the phases of the oscillations can be altered. The disruption of the circadian molecular clock may result in a number of metabolic disorders including obesity and diabetes (Durgan & Young, 2010; Froy, 2010; Green et al., 2008; Maury et al., 2010; Sookoian et al., 2008; Takahashi et al., 2008). "
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