A case report of myopathy from consumption of red yeast rice.

Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, 6550 Fannin Street, M.S. A-601, Houston, TX 77030, USA.
Journal of Clinical Lipidology (Impact Factor: 3.59). 02/2008; 2(1):60-2. DOI: 10.1016/j.jacl.2007.12.005
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    Journal of pharmaceutical and biomedical analysis 02/2014; 94C:196-202. DOI:10.1016/j.jpba.2014.01.018 · 2.83 Impact Factor
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    ABSTRACT: Red yeast rice (i.e., rice fermented with Monascus spp.) is currently sold via the Internet as a dietary supplement. Claims state that red yeast rice has the ability to lower blood cholesterol concentrations. The mechanism of action is well characterised because the red yeast rice constituent monacolin K is identical with lovastatin, an inhibitor of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase that is used in many cholesterol-lowering medicinal products. The aim of this article is to evaluate the properties of red yeast rice products that are marketed via the Internet. Three out of five analyzed products may reach the daily dosage of 10 mg lovastatin, which is necessary for the substantiation of health claims on the maintenance of normal blood LDL-cholesterol levels as suggested by the Scientific Opinion of the European Food Safety Authority. 10 mg is also the starting dosage of medicinal lovastatin products on the German market. From a regulatory standpoint, red yeast rice products would rather have to be sold as medicinal products than as food supplements as they clearly exhibit a pharmacological action that is comparable to approved statin-containing medicinal products. This also implies potential adverse effects and interactions, about which the consumer is insufficiently informed in the case of food supplements. The lack of control over the Internet market is evidenced by the fact that four of the tested products were not marketable in conventional trade in Germany due to violations of labelling rules.
    Deutsche Lebensmittel-Rundschau: Zeitschrift für Lebensmittelkunde und Lebensmittelrecht 07/2012; 108(7):357-360. · 0.06 Impact Factor