Inter-generational continuity in periodontal health: findings from the Dunedin Family History Study

Department of Oral Sciences, School of Dentistry, Dunedin, New Zealand Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, England.
Journal Of Clinical Periodontology (Impact Factor: 4.01). 04/2011; 38(4):301-9. DOI: 10.1111/j.1600-051X.2011.01704.x
Source: PubMed

ABSTRACT To determine whether parental periodontal disease history is a risk factor for periodontal disease in adult offspring.
Proband periodontal examination [combined attachment loss (CAL) at age 32, and incidence of CAL from ages 26 to 32] and interview data were collected during the age-32 assessments in the Dunedin Study. Parental data were also collected. The sample was divided into two familial-risk groups for periodontal disease (high- and low-risk) based on parents' self-reported periodontal disease.
Periodontal risk analysis involved 625 proband-parent(s) groups. After controlling for confounding factors, the high-familial-risk periodontal group was more likely to have 1+ sites with 4+mm CAL [relative risk (RR) 1.45; 95% confidence interval (CI) 1.11-1.88], 2+ sites with 4+mm CAL (RR 1.45; 95% CI 1.03-2.05), 1+ sites with 5+mm CAL (RR 1.60; 95% CI 1.02-2.50), and 1+ sites with 3+mm incident CAL (RR 1.64; 95% CI 1.01-2.66) than the low-familial-risk group. Predictive validity was enhanced when information was available from both parents.
Parents with poor periodontal health tend to have offspring with poor periodontal health. Family/parental history of oral health is a valid representation of the shared genetic and environmental factors that contribute to an individual's periodontal status, and may help to predict patient prognosis and preventive treatment need.

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Available from: William Murray Thomson, Sep 28, 2015
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    • "Pediatrician Thomas Boyce and colleagues studying 5-year old children have demonstrated how psychosocial , infectious, and stress-related processes seem to converge in the development of caries and thus contribute to increasing the risk that future, overall dental health be impaired [13]. The highly acknowledged, prospective Dunedin Study from New Zealand, which followed the impact of psychosocial distress on children over a period of years, has shown a clear correlation between the dental health of the children and that of their parents, reflecting social gradients [88]. In a recent US study, allostatic load, impaired dental health, and low sociocultural status have also been shown to be associated [12]. "
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    ABSTRACT: During the past two decades, increasing recognition has been given to a relationship between oral health and systemic diseases. Associated systemic conditions include cardiovascular disease, diabetes, low birth weight and preterm births, respiratory diseases, rheumatoid arthritis, obesity, osteoporosis, and, in particular among oral conditions, periodontal disease. Low-grade inflammation is a common denominator linking these disorders. Applying an anecdotal approach and an integrative view, the medical and dental histories of two women document increasing ill health subsequent to incidences of maltreatment and sexual abuse, including oral penetration, at an early age. Comprehensive oral rehabilitation was required in both cases. These cases open for medical insight with regard to their implicit patho-physiology, when integrated with current evidence from neuroscience, endocrinology, and immunology, converging in the concepts of allostasis and allostatic load. In cases such as those presented in this paper, primary care physicians (family doctors, General Practitioners) and dentists may be the first to identify an etiological pattern. This report underlines the importance of increased and enhanced multidisciplinary research cooperation among health professionals. Our hypothesis is that childhood adversity may affect all aspects of human health, including adult oral health. Copyright © 2015. Published by Elsevier Ltd.
    Medical Hypotheses 04/2015; 85(2). DOI:10.1016/j.mehy.2015.04.020 · 1.07 Impact Factor
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    • "The combined attachment loss (CAL) for each site was calculated by summing gingival recession and probing depth. The diagnostic of periodontal disease was defined by the association of gingival bleeding and clinical attachment loss (CAL) ≥ 4 mm in two or more sites [7]. Biopsies and exfoliative cytology were performed according to diagnostic needs. "
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    ABSTRACT: The aim of this study was to assess the prevalence of oral lesions in infectious-contagious diseases patients being treated in the University Hospital of the Federal University of Pará, northern Brazil. One hundred seven patients with infectious diseases were clinically investigated for oral lesions at the University Hospital of Pará, northern Brazil. From total sample, most patients were men (65.7%) with a mean age of 45.4 years. About prevalence of systemic diseases, tuberculosis was the most frequent illness, followed by AIDS, hepatitis types B and C, leishmaniasis, and meningitis. Analyzing oral manifestations, periodontal diseases and candidiasis were the most prevalent diseases in both genders, followed by recurrent aphthous ulcers, saburral tongue, simplex herpes, and squamous cell carcinoma. Of all 107 patients, only 10 males and 6 females did not present any oral manifestation. There was no statistical difference between genders with any systemic condition ( P > 0.05 ). The great prevalence of oral manifestations in hospitalized patients with systemic disorder emphasizes the need of integral dental care in this context, aiming at a multidisciplinary approach of patients. Therefore, presence of some oral conditions, such as candidiasis, should be an alert to different systemic conditions, once in assistance with physicians; dentists can influence the early diagnosis and treatment.
    The Scientific World Journal 01/2014; 2014(1):586075. DOI:10.1155/2014/586075 · 1.73 Impact Factor
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    • "nicity Higher prevalence of periodontitis in non - Hispanic black and Mexican - Americans compared with non - Hispanic Whites ( Burt 2005 ) Socioeconomic Status Periodontal disease is associated with socioeconomic status ( Burt 2005 ) Genetics IL - 1 positive genotype associated with more severe periodontitis ( Burt 2005 ; Pihlstrom et al . 2005 ; Shearer et al . 2011 )"
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