A pilot study on zinc levels in patients with rheumatoid arthritis.

Independent Laboratory of Family Physician Education, Pomeranian Medical University, ul. Rybacka 1, 70-204, Szczecin, Poland.
Biological trace element research (Impact Factor: 1.61). 11/2011; 143(2):854-62. DOI: 10.1007/s12011-010-8952-2
Source: PubMed

ABSTRACT The aim of the study was to evaluate zinc levels in three biological compartments (serum, erythrocytes and hair) in patients with rheumatoid arthritis (RA) as compared to healthy individuals. Zinc levels in serum, erythrocytes and hair (in 74 patients with RA and 30 healthy individuals) were assessed by atomic absorption spectroscopy. The mean hair zinc content was significantly lower in RA patients as compared to healthy individuals (p<0.001). Moreover, a positive correlation was observed in the RA patient group between the erythrocyte zinc levels and the prednisone dose (rs=0.48, p<0.05), and a negative correlation was found in this population between the serum zinc levels and disease duration (rs=-0.42, p<0.0006). In conclusion, it seems that hair may be a useful complementary study material for evaluating "zinc status" in rheumatoid arthritis patients.

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: BACKGROUND: Hair analysis is used for estimation of the nutritional status of individuals. In the present work, a systematic review on the relation between the mineral composition of hair and the physical or mental disorders is discussed. Detailed information of examined populations, methods of sample preparations and analytical techniques are presented. METHODS: A systematic literature search in four electronic databases Scopus, PubMed, Web of Science and Medline (from 1997 to 2012/01/31) for English language articles was performed. In addition, a reference list and manual search was undertaken. RESULTS: The following number of studies was included: 66. Most of the authors reported that there exists a correlation between deficiency or excess of some elements in hair and occurrence of some diseases, such as: autism, cancer, hypertension, myocardial infarction, kidney disease and diabetes mellitus. However, not all results were consistent. CONCLUSIONS: Most of the authors concluded that the profile of hair mineral imbalance might be useful as a diagnostic tool for the early diagnosis of many diseases. However, it seems that there is a need to standardize sample preparation procedures, in particular washing and mineralization methods.
    Clinica chimica acta; international journal of clinical chemistry 04/2013; 419:139-171. DOI:10.1016/j.cca.2013.02.001 · 2.76 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: This work presents a comparative evaluation of the performance of four types of wave-plate drift eliminator commonly used in mechanical cooling towers, with similar morphology. The droplet collection efficiency and the coefficient of pressure drop are numerically calculated, for values of inlet velocity 1≤Ue≤5m/s and droplet diameter 2≤Dp≤50μm, with Reynolds number and inertial parameter roughly in the ranges 650≤Re≤8500 and 0.05≤Pi≤2.5, respectively. The numerical model has been validated through comparisons with numerical and experimental results taken from the literature, including additional configurations of horizontal wave-plate mist separators. The effects of considering the turbulence dispersion of droplets are studied, as well as the influence of the inertial parameter and the aspect ratio of the eliminator sample channel. Best results are obtained by using the SST k−ω turbulence model, with values of non-dimensional scaled distance to wall y+ comprised in the range 0.2–0.5, including the turbulent dispersion of droplets. A global correlation for the collection efficiency is proposed, as a function of the inertial parameter and the removal geometric parameter, which is introduced in this work. Finally, it is developed a procedure focused on establishing the overall efficiency for each type of eliminator, based in a key power function.
    Chemical Engineering Science 03/2011; 66(6):1232-1245. DOI:10.1016/j.ces.2010.12.023 · 2.61 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex, incompletely understood, etiology. Several genetic and environmental factors are suspected to be involved in its aetiology. Oxidative stress may be implicated in the pathogenesis of SLE and may be affected by trace element status. Zinc (Zn), copper (Cu) and selenium (Se) are essential components of several anti-oxidative enzymes and are also involved in several immune functions. The current study aimed to assess the relationship between serum concentrations of these trace elements and the clinical disease activity of SLE assessed using the SLE disease activity index (SLEDAI). Serum concentrations of albumin (Alb) (p = 0.001), Se (p = 0.001), Zn (p = 0.001) and the Zn to Cu ratio (Zn/Cu R) (p = 0.001) were lower in patients with SLE than the age- and sex-matched healthy controls. However, only Alb (p = 0.001) and Cu (p = 0.03) were negatively correlated with disease activity, which was supported by regression analysis. In summary, lower serum values of Alb, Zn, Se and Zn/Cu R were found in SLE patients compared with healthy controls; however, in addition to serum Alb concentrations, serum Cu concentrations were also negatively correlated with lupus disease activity.
    Lupus 04/2014; 23(8). DOI:10.1177/0961203314530792 · 2.48 Impact Factor


Available from