A Pilot Study on Zinc Levels in Patients with Rheumatoid Arthritis

Independent Laboratory of Family Physician Education, Pomeranian Medical University, ul. Rybacka 1, 70-204, Szczecin, Poland.
Biological trace element research (Impact Factor: 1.75). 11/2011; 143(2):854-62. DOI: 10.1007/s12011-010-8952-2
Source: PubMed


The aim of the study was to evaluate zinc levels in three biological compartments (serum, erythrocytes and hair) in patients with rheumatoid arthritis (RA) as compared to healthy individuals. Zinc levels in serum, erythrocytes and hair (in 74 patients with RA and 30 healthy individuals) were assessed by atomic absorption spectroscopy. The mean hair zinc content was significantly lower in RA patients as compared to healthy individuals (p < 0.001). Moreover, a positive correlation was observed in the RA patient group between the erythrocyte zinc levels and the prednisone dose (r
s = 0.48, p < 0.05), and a negative correlation was found in this population between the serum zinc levels and disease duration (r
s = −0.42, p < 0.0006). In conclusion, it seems that hair may be a useful complementary study material for evaluating “zinc status” in rheumatoid arthritis patients.

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    • "160 . 9 ± 27 . 4 190 . 8 ± 29 . 9 b0 . 001 AAS Mierzecki et al . 2011 [ 229 ] 177 . 6 ± 72 . 6 [ 155 . 7 – 196 . 0 ] b 209 . 1 ± 92 . 9 [ 189 . 7 – 248 . 8 ] b ns AAS Wang et al . 2009 [ 230 ] Cu / Zn 0 . 33 ± 0 . 11 [ 0 . 31 – 0 . 38 ] b 0 . 16 ± −0 . 12 [ 0 . 11 – 0 . 19 ] b b0 . 001 Wang et al . 2009 [ 230 ] Fe / Cu 1 . 47 ± 0 . 88 [ 1 . 19 – 1 . 72 ] b 2 . 71 ± 2 . 03 [ 2 . 25 – 3 . 56 ] b b0 . 01 Wan"
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    • "It has been reported in literature that reactive oxygen species play a key role in the etiology of RA (Cerhan et al., 2003; Sarban et al., 2005; Fautrel and Bourgeois, 2000; Piotrowska-Jastrzębska et al., 2002; Sarban et al., 2007) and that one of them is the superoxide radical, which is eliminated by superoxide dismutase—an enzyme containing zinc in its molecule (Tapiero and Tew, 2003). It has also been found that over 90% of this trace element present in erythrocytes is bound with carbonic anhydrase and superoxide dismutase (Mierzecki et al., DOI 10.1007/ s12011-010-8952-2). "
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