Carcinoid tumour associated with enterovirus infection

EV Med Research, Lomita, California 90717, USA.
Journal of clinical pathology (Impact Factor: 2.92). 07/2011; 64(8):722-4. DOI: 10.1136/jcp.2010.082271
Source: PubMed


Enteroviruses commonly infect the gastrointestinal tract, and replication of enteroviruses has been well documented in the Peyer patches of the small bowel. Chronic enterovirus infection has been found in the stomach and terminal ileum of patients with myalgic encephalomyelitis/chronic fatigue syndrome. The authors report the unexpected finding of enterovirus VP1 protein, by immunoperoxidase staining, in carcinoid tumours found in one patient with myalgic encephalomyelitis/chronic fatigue syndrome and another patient with chronic lower quadrant abdominal pain, and suggest a possible association between enteroviruses and tumorigenesis.

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    • "EV71-infected children can develop severe neurological complications, which can lead to rapid clinical deterioration and even death7,8). Additionally, some reports have suggested that enteroviral diseases may be expanded to other serious human ailments such as autoimmunity, type 1 diabetes9), Sj√∂gren's syndrome10), various neurological disorders11), and some tumors12). "
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    ABSTRACT: Although most enterovirus infections are not serious enough to be life threatening, several enteroviruses such as enterovirus 71 are responsible for severe, potentially life-threatening disease. The epidemic patterns of enteroviruses occur regularly during the year, but they may change due to environmental shifts induced by climate change due to global warming. Therefore, enterovirus epidemiological studies should be performed continuously as a basis for anti-viral studies. A great number of synthesized antiviral compounds that work against enteroviruses have been developed but only a few have demonstrated effectiveness in vivo. No proven effective antiviral agents are available for enterovirus disease therapy. The development of a new antiviral drug is a difficult task due to poor selective toxicity and cost. To overcome these limitations, one approach is to accelerate the availability of other existing antiviral drugs approved for antiviral effect against enteroviruses, and the other way is to screen traditional medicinal plants.
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