Article

Serotonin transporter and memory

Depto. de Farmacobiología, CINVESTAV-IPN, Tenorios 235, Granjas Coapa, Mexico City 14330, Mexico.
Neuropharmacology (Impact Factor: 4.82). 09/2011; 61(3):355-63. DOI: 10.1016/j.neuropharm.2011.01.018
Source: PubMed

ABSTRACT The serotonin transporter (SERT) has been associated to diverse functions and diseases, though seldom to memory. Therefore, we made an attempt to summarize and discuss the available publications implicating the involvement of the SERT in memory, amnesia and anti-amnesic effects. Evidence indicates that Alzheimer's disease and drugs of abuse like d-methamphetamine (METH) and (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") have been associated to decrements in the SERT expression and memory deficits. Several reports have indicated that memory formation and amnesia affected the SERT expression. The SERT expression seems to be a reliable neural marker related to memory mechanisms, its alterations and potential treatment. The pharmacological, neural and molecular mechanisms associated to these changes are of great importance for investigation.

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Available from: Georgina Perez, May 05, 2014
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    • "Cortical serotonin activity has been well characterized for its role in affective disorders (Vaswani et al., 2003), but much less studied in cortically-based recognition memory dysfunction. Emerging evidence suggests that cortical and hippocampal SERT expression is important for memory formation (Meneses et al., 2011). With regard to recognition memory, SERT knockout rats show pronounced deficits (Olivier et al., 2009), and both chronic and acute tryptophan (i.e., serotonin precursor) depletion impaired object-recognition memory in rats (Jenkins et al., 2010; Olivier et al., 2008). "
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