Article

Clinical significance of STC1 gene expression in patients with colorectal cancer.

Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Anticancer research (impact factor: 1.73). 01/2011; 31(1):325-9. pp.325-9
Source: PubMed

ABSTRACT Recent studies suggest that altered patterns of stanniocalcin 1 (STC1) gene expression have a role in human carcinogenesis. This study examined the relationship between the relative expression of the STC1 gene and clinicopathological factors in patients with colorectal cancer.
Surgical specimens of cancer tissue and adjacent normal mucosa were obtained from 202 patients with colorectal carcinomas. The relative expression levels of STC1 mRNA in the cancer and the normal adjacent mucosa were measured by quantitative real-time, reverse-transcriptase polymerase chain reaction.
The relative expression levels of the STC1 gene were higher in the cancer tissue than in the normal adjacent mucosa and high expression of STC1 correlated with poor postoperative survival.
High expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer.

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Keywords

adjacent normal mucosa
 
altered patterns
 
cancer tissue
 
colorectal cancer
 
colorectal carcinomas
 
human carcinogenesis
 
normal adjacent mucosa
 
poor postoperative outcome
 
quantitative real-time
 
Recent studies
 
relative expression
 
relative expression levels
 
reverse-transcriptase polymerase chain reaction
 
stanniocalcin 1
 
STC1
 
STC1 correlated
 
STC1 gene
 
STC1 mRNA