Chemical Composition and Antiproliferative Activity of Essential Oil from the Leaves of a Medicinal Herb, Levisticum officinale, against UMSCC1 Head and Neck Squamous Carcinoma Cells

Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
Anticancer research (Impact Factor: 1.83). 01/2011; 31(1):185-91.
Source: PubMed


Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC).
Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses.
Lovage essential oil extract had an IC₅₀ value of 292.6 μg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling.
Levisticum officinale essential oil inhibits human HNSCC cell growth.

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    • "More than 50% anticancer drugs are produced from natural products and their derivatives [4] and some of them are approved by the United States Food and Drug Administration [5]. Many anticancer drugs for OSCC were developed from natural products, such as genistein from soybeans [2] [6], honokiol from Magnolia species [7], extracts of deep-water Marion Island sponges [8], essential oil from Levisticum officinale [9], cytotoxic limonoid from Chisocheton erythrocarpus [10], and others. Because OSCC therapy is not satisfactory with use of a single natural product, other natural products with anti-oral cancer activity are worthy of discovery. "
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