"Till and McCulloch published a seminal paper, which was published in its original form again this year, providing a quantitative method for analyzing hematopoietic cells capable of continued proliferation in vivo and providing a singularly important observation that single cells could give rise to all hematopoietic lineages in vivo (Till and McCulloch, 1961, 2011; Weissman, 2011). Supralethally irradiated mice were injected with nucleated bone marrow cells and the spleen colony-forming units quantified. "
[Show abstract][Hide abstract] ABSTRACT: This is a chronicle of concepts in the field of epidermal stem cell biology and a historic look at their development over time. The past 25 years have seen the evolution of epidermal stem cell science, from first fundamental studies to a sophisticated science. The study of epithelial stem cell biology was aided by the ability to visualize the distribution of stem cells and their progeny through lineage analysis studies. The excellent progress we have made in understanding epidermal stem cell biology is discussed in this article. The challenges we still face in understanding epidermal stem cells include defining molecular markers for stem and progenitor sub-populations, determining the locations and contributions of the different stem cell niches, and mapping regulatory pathways of epidermal stem cell proliferation and differentiation. However, our rapidly evolving understanding of epidermal stem cells has many potential uses that promise to translate into improved patient therapy.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.