Article

Clinical features and successful management of suicidal digoxin toxicity without use of digoxin-specific antibody (Fab) fragments--is it possible?

Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Niayesh Street, Sattar-Khan Avenue, 1445613131, Tehran, Iran.
Tropical Doctor (impact factor: 0.66). 01/2011; 41(2):108-10. DOI:10.1258/td.2010.100195 pp.108-10
Source: PubMed

ABSTRACT A retrospective study of 147 consecutive cases of suicidal digoxin poisoning was undertaken in order to determine the severity and outcome of toxicity without use of digoxin-specific Fab fragments. This study showed that suicidal digoxin poisoning in young patients is usually mild to moderate; even underlying cardiac disease and chronic use of digoxin has no effect on the severity of toxicity and incidence of lethal dysrhythmia in these cases. This type of toxicity responds appropriately to conventional treatment.

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Keywords

147 consecutive cases
 
cases
 
conventional treatment
 
digoxin
 
digoxin-specific Fab fragments
 
moderate
 
retrospective study
 
severity
 
suicidal digoxin poisoning