Low-Grade Myofibroblastic Sarcoma of the Larynx
National Cancer Institute Regina Elena, Rome, Italy.International Journal of Surgical Pathology (Impact Factor: 0.95). 02/2011; 19(6):822-6. DOI: 10.1177/1066896910393958
Low-grade myofibroblastic sarcoma is an uncommon sarcoma with myofibroblastic differentiation. It occurs in a wide variety of sites and has a predilection for the head and neck region. Biologically, low-grade myofibroblastic sarcoma has a propensity for local recurrence and is associated with a low risk of metastatic spread. Histologically, it can mimic a variety of different types of benign and malignant processes and often requires immunohistochemical analysis for its accurate identification. This report describes a case and discusses the differential diagnosis of a low-grade myofibroblastic sarcoma that arose in the larynx of a 69-year-old woman with a history of metastatic skin melanoma. To the best of the authors' knowledge this is the first description in the English literature of low-grade myofibroblastic sarcoma originating in the larynx.
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ABSTRACT: Mesenchymal neoplasms of the larynx are rare and make up approximately 0.3% to 1.0% of all malignancies at this location. Low grade myofibroblastic sarcoma (LGMS) of larynx is a rare entity. We describe a rare case of LGMS of larynx who presented with complaint of hoarseness of voice. The patient was treated with total laryngectomy plus partial pharyngectomy followed by post-operative radiotherapy. Histopathologically, the lesion was composed of spindle cells that manifested variable cellular anaplasia and expressed smooth muscle actin (SMA) and focally S-100.One of the resection limits was involved so patient was given post-operative radiotherapy. The patient is alive and disease free 14 months after surgery. The characteristic clinical, histopathological features and treatment of this case are described with a literature review.Journal of cancer research and therapeutics 04/2013; 9(2):284-6. DOI:10.4103/0973-1482.113387 · 0.79 Impact Factor
Conference Paper: Low-grade myofibroblastický sarkom hrtanu5. česko – slovenský kongres otorinolaryngologie a chirurgie hlavy a krku, 75. kongres České společnosti otorinolaryngologie a chirurgie hlavy a krku ČLS JEP a 60. kongres Slovenskej spolocnosti pre ORL a chirurgiu hlavy a krku, Hradec Kralove; 05/2013
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ABSTRACT: Low-grade myofibroblastic sarcoma (LGMFS) is considered a distinct entity in the World Health Organization classification of soft tissue neoplasms, defined as an atypical myofibroblastic proliferation with fibromatosis-like features and a predilection for the head and neck. A substantial subset of previously reported myofibroblastic sarcomas (MFS), particularly in the head and neck region, are associated with appreciable tumor-associated morbidity and mortality and should be differentiated from the more indolent LGMFS. However, no specific morphological criteria have been developed to define the entity of LGMFS. We have reviewed histological findings in conjunction with clinical follow-up information of previously reported MFS in the head and neck region in the English literature, with the addition of five new cases from our institution. We found that MFSs with 6 or more mitoses per 10 high power fields and/or presence of spontaneous necrosis were accompanied by a higher mortality rate that is statistically significant.Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 10/2013; 463(6). DOI:10.1007/s00428-013-1494-1 · 2.65 Impact Factor
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