Pleuropericardial effusion after 37 years of sulfasalazine therapy.
ABSTRACT Pleural and pericardial effusions can be a rare feature of inflammatory bowel disease. However, even more uncommonly, it can be attributed to the therapy for the same. Sulfasalazine causing an isolated pleuropericardial effusion, especially after many years of therapy, has never been reported in English literature. Although, this feature can be a component of drug-induced lupus erythematosus, the clinical presentations reported are rare and have been associated with arthralgia, rash, hematological manifestations and a positive antihistone, all of which were absent in our patient. An objective causality assessment using the Naranjo probability scale suggested that sulfasalazine was the probable cause of pleuropericardial effusion in our patient.