Article

Ring B aromatic norpimarane glucoside from a Xylaria sp.

National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
Journal of Natural Products (impact factor: 3.13). 01/2011; 74(2):300-2. DOI:10.1021/np100873t
Source: PubMed

ABSTRACT A novel 20-norpimarane glucoside, xylopimarane (1), together with the known sphaeropsidin C (2) and clonostachydiol (3), was isolated from the fungus Xylaria sp. BCC 4297. Compound 1 exhibited cytotoxicity to cancer cell lines KB, MCF-7, and NCI-H187 with respective IC(50) values of 1.0, 13, and 65 μM.

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Keywords

cancer cell lines KB
 
Compound 1 exhibited cytotoxicity
 
fungus Xylaria sp
 
known sphaeropsidin C
 
novel 20-norpimarane glucoside
 
respective IC(50)