An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity

Department of Biomedical Engineering, Washington University in St Louis, MO 63130, USA.
Nanoscale (Impact Factor: 6.74). 01/2011; 3(3):950-3. DOI: 10.1039/c0nr00874e
Source: PubMed

ABSTRACT A gold nanocage and dye conjugate has been demonstrated for use with photoacoustic imaging and fluorescence detection of protease activity. The detection sensitivity could be maximized by using gold nanocages with a localized surface plasmon resonance peak away from the emission peak of the dye. These hybrids can be potentially used as multimodal contrast agents for molecular imaging.

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