Article

[Prediction of clinical course of glioblastomas by MRI during radiotherapy].

Radiologische Klinik, FE Strahlentherapie, Universitätsklinik Bonn, Bonn, Deutschland.
Strahlentherapie und Onkologie (impact factor: 3.56). 12/2010; 186(12):681-6. DOI:10.1007/s00066-010-2156-8 pp.681-6
Source: PubMed

ABSTRACT determine the value of MR studies in patients undergoing radiotherapy for glioblastomas pre and during radiotherapy to predict the clinical course.
MR follow-up studies were performed in 33 patients with glioblastomas before radiotherapy, after 30 Gy, after 60 Gy, and in the treatment follow-up. Findings on MR were categorized into: definite progress, questionable progress, status idem. Patients were followed clinically (median for 11 months).
after 30 Gy 23/33 (70%) of the MR examination showed status idem. 10/33 (30%) demonstrated definite (n = 6) or questionable (n = 4) progress. Further tumor progress was faster in these patients and patients succumb to their disease earlier (9 vs. 22 months). The 60 Gy study showed definite (n = 8) and questionable (n = 6) progress in 14/33 (42%) cases. All these tumors were progressing faster and were associated with a comparatively reduced life expectancy.
MR follow-up studies after 30 Gy in patients undergoing radiotherapy for glioblastomas allow for prognostic appraisal, and potentially early modification of treatment.

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Keywords

11 months
 
22 months
 
33 patients
 
60 Gy study
 
clinical course
 
clinically
 
definite progress
 
glioblastomas pre
 
MR examination
 
MR follow-up studies
 
MR studies
 
patients
 
patients succumb
 
patients undergoing radiotherapy
 
questionable
 
questionable progress
 
reduced life expectancy
 
treatment follow-up
 
tumor progress
 
tumors