Natural anti-inflammatory agents for pain relief. Surg Neurol Int 1:80

Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Surgical Neurology International (Impact Factor: 1.18). 12/2010; 1(1):80. DOI: 10.4103/2152-7806.73804
Source: PubMed

ABSTRACT The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended in a typical neurosurgical practice. But persistent long-term use safety concerns must be considered when prescribing these medications for chronic and degenerative pain conditions. This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side effects of nonsteroidal drugs and commonly used and clinically studied natural alternative anti-inflammatory supplements. Although nonsteroidal medications can be effective, herbs and dietary supplements may offer a safer, and often an effective, alternative treatment for pain relief, especially for long-term use.

1 Follower
  • Source
    • "ed curcumin's antioxidant, antiinflammatory , and antineoplastic effects. Most studies to date has been performed in animals, but given the centuries of use of curcumin , as well as its now demonstrated activity in the NF-B, COX-1, and COX-2 inflammatory pathways, it may be considered a viable natural alternative for the treatment of inflammation (Maroon et. al, 2010)."
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: There are many medications and traditional remedy in treating mouth ulcers. This study aimed to compare the effectiveness between turmeric and triamcinolone in treating minor recurrent aphthous ulcer in oral cavity. Materials and Methods: The effectiveness of healing ulcer measured using two parameters, which are the ulcer size and pain score. Twenty patients (n = 20) with minor recurrent aphthous stomatitis were volunteered to join the study, with no known medical illness. Subjects were divided into two groups. One group received triamcinolone acetonide (0.1%) and the other group received turmeric powder. The subjects were required to apply the medication twice per day. Ulcer size and pain were been measured on treatment days 1 and 5. Data were analyzed using t test for independent sample. Results: No significant differences were been found between the two groups studied. In conclusion, the two treatments applied had similar effectiveness as they both relieved pain and reduced the size of recurrent aphthous ulcers. Conclusion: Still, as an alternative, the turmeric can be used for treating minor recurrent aphthous ulcer meanwhile the tri-amcinolone cannot be used in long term management in treating the ulcer.
    International Medical Journal (1994) 06/2013; 20(3):392-394. · 0.09 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: While numerous laboratory studies have searched for neuroprotective treatment approaches to traumatic brain injury, no therapies have successfully translated from the bench to the bedside. Concussion is a unique form of brain injury, in that the current mainstay of treatment focuses on both physical and cognitive rest. Treatments for concussion are lacking. The concept of neuro-prophylactic compounds or supplements is also an intriguing one, especially as we are learning more about the relationship of numerous sub-concussive blows and/or repetitive concussive impacts and the development of chronic neurodegenerative disease. The use of dietary supplements and herbal remedies has become more common place. A literature search was conducted with the objective of identifying and reviewing the pre-clinical and clinical studies investigating the neuroprotective properties of a few of the more widely known compounds and supplements. There are an abundance of pre-clinical studies demonstrating the neuroprotective properties of a variety of these compounds and we review some of those here. While there are an increasing number of well-designed studies investigating the therapeutic potential of these nutraceutical preparations, the clinical evidence is still fairly thin. There are encouraging results from laboratory studies demonstrating the multi-mechanistic neuroprotective properties of many naturally occurring compounds. Similarly, there are some intriguing clinical observational studies that potentially suggest both acute and chronic neuroprotective effects. Thus, there is a need for future trials exploring the potential therapeutic benefits of these compounds in the treatment of traumatic brain injury, particularly concussion.
    Surgical Neurology International 01/2011; 2(1):146. DOI:10.4103/2152-7806.85987 · 1.18 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Traditionally, the medical management of concussion has involved close observation and physical and cognitive rest. Most postconcussive symptoms resolve spontaneously and require only conservative treatment. However, some patients have prolonged recoveries and may benefit from treatment with medications. Some naturally occurring compounds demonstrate multimechanistic neuroprotective properties and may be potential treatment considerations. For the most part, however, current treatments are symptom based for those with persistent postconcussive symptoms. The evidence supporting the various pharmacologic treatments in concussion is equivocal. The choice of which medication to use for a patient depends on the symptom characteristics, and each decision should be made on an individual-case basis. There is a need for well-designed trials investigating the efficacy of various medical therapies.
    Neurosurgery 01/2012; 70(6):1520-33; discussion 1533. DOI:10.1227/NEU.0b013e31824cebe8 · 3.03 Impact Factor
Show more