Natural anti-inflammatory agents for pain relief. Surg Neurol Int 1:80
Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Surgical Neurology International
(Impact Factor: 1.18).
12/2010; 1(1):80. DOI: 10.4103/2152-7806.73804
The use of both over-the-counter and prescription nonsteroidal medications is frequently recommended in a typical neurosurgical practice. But persistent long-term use safety concerns must be considered when prescribing these medications for chronic and degenerative pain conditions. This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side effects of nonsteroidal drugs and commonly used and clinically studied natural alternative anti-inflammatory supplements. Although nonsteroidal medications can be effective, herbs and dietary supplements may offer a safer, and often an effective, alternative treatment for pain relief, especially for long-term use.
Available from: Marcelo Franchin
- "The major bioactive constituents of Camellia sinensis are catechins, which may have participated in the acute anti-inflammatory activity of the tea decoction evaluated using paw edema induced by carrageenan and dextran . Many biological effects have been reported for (+) catechins, including anticarcinogen, cardiopreventive, antimicrobial, anti-viral, neuro-protective  and anti-inflammatory  effects. Similarly, the epicathechin identified in the guava pomace extract could be related with the anti-inflammatory effects showed in paw edema models induced by different phlogistic agents (Tables 1, 2, 3, 4) and neutrophils migration in the peritoneal cavity (Figure 1). "
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ABSTRACT: Guava pomace is an example of the processing waste generated after the manufacturing process from the juice industry that could be a source of bioactives. Thus, the present investigation was carried out in order to evaluate the anti-inflammatory and antinociceptive potential and determinate the main phenolic compounds of a guava pomace extract (GPE).
The anti-inflammatory activity was evaluated by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models. Acetic acid-induced abdominal writhing and formalin test were performed to investigate the antinociceptive effects. In addition, the content of total phenolic and of individual phenolic compounds was determined by GC/MS.
GPE showed anti-inflammatory activity by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models (p < 0.05). GPE also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test (p < 0.05). The total phenolic value was 3.40 +/- 0.09 mg GAE/g and epicatechin, quercetin, myricetin, isovanilic and gallic acids were identified by GC/MS analysis.
The presence of bioactive phenolic compounds as well as important effects demonstrated in animal models suggest that guava pomace could be an interesting source of anti-inflammatory and analgesic substances.
BMC Complementary and Alternative Medicine 09/2013; 13(1):235. DOI:10.1186/1472-6882-13-235 · 2.02 Impact Factor
Available from: Mohammad Khursheed Alam
- "ed curcumin's antioxidant, antiinflammatory , and antineoplastic effects. Most studies to date has been performed in animals, but given the centuries of use of curcumin , as well as its now demonstrated activity in the NF-B, COX-1, and COX-2 inflammatory pathways, it may be considered a viable natural alternative for the treatment of inflammation (Maroon et. al, 2010)."
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ABSTRACT: Background: There are many medications and traditional remedy in treating mouth ulcers. This study aimed to compare the effectiveness between turmeric and triamcinolone in treating minor recurrent aphthous ulcer in oral cavity. Materials and Methods: The effectiveness of healing ulcer measured using two parameters, which are the ulcer size and pain score. Twenty patients (n = 20) with minor recurrent aphthous stomatitis were volunteered to join the study, with no known medical illness. Subjects were divided into two groups. One group received triamcinolone acetonide (0.1%) and the other group received turmeric powder. The subjects were required to apply the medication twice per day. Ulcer size and pain were been measured on treatment days 1 and 5. Data were analyzed using t test for independent sample. Results: No significant differences were been found between the two groups studied. In conclusion, the two treatments applied had similar effectiveness as they both relieved pain and reduced the size of recurrent aphthous ulcers. Conclusion: Still, as an alternative, the turmeric can be used for treating minor recurrent aphthous ulcer meanwhile the tri-amcinolone cannot be used in long term management in treating the ulcer.
International Medical Journal (1994) 06/2013; 20(3):392-394. · 0.09 Impact Factor
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ABSTRACT: While numerous laboratory studies have searched for neuroprotective treatment approaches to traumatic brain injury, no therapies have successfully translated from the bench to the bedside. Concussion is a unique form of brain injury, in that the current mainstay of treatment focuses on both physical and cognitive rest. Treatments for concussion are lacking. The concept of neuro-prophylactic compounds or supplements is also an intriguing one, especially as we are learning more about the relationship of numerous sub-concussive blows and/or repetitive concussive impacts and the development of chronic neurodegenerative disease. The use of dietary supplements and herbal remedies has become more common place.
A literature search was conducted with the objective of identifying and reviewing the pre-clinical and clinical studies investigating the neuroprotective properties of a few of the more widely known compounds and supplements.
There are an abundance of pre-clinical studies demonstrating the neuroprotective properties of a variety of these compounds and we review some of those here. While there are an increasing number of well-designed studies investigating the therapeutic potential of these nutraceutical preparations, the clinical evidence is still fairly thin.
There are encouraging results from laboratory studies demonstrating the multi-mechanistic neuroprotective properties of many naturally occurring compounds. Similarly, there are some intriguing clinical observational studies that potentially suggest both acute and chronic neuroprotective effects. Thus, there is a need for future trials exploring the potential therapeutic benefits of these compounds in the treatment of traumatic brain injury, particularly concussion.
Surgical Neurology International 01/2011; 2(1):146. DOI:10.4103/2152-7806.85987 · 1.18 Impact Factor
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