Article

Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: a controlled prospective study.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (impact factor: 2.39). 12/2010; 35(6):486-9. DOI:10.1111/j.1749-4486.2010.02201.x pp.486-9
Source: PubMed

ABSTRACT To evaluate the therapeutic efficacy of coenzyme Q10 added to systemic steroid in patients with idiopathic sudden sensorineural hearing loss.
A controlled prospective study.
Asan medical center, University of Ulsan College of Medicine.
Between August 2007 and October 2008, the first 60 patients diagnosed with sudden sensorineural hearing loss were managed with systemic steroid treatment for 2 weeks including 5-day hospitalisation. And the second 60 patients were managed with coenzyme Q10 for 2 weeks added to previous management.
We evaluated auditory function by pure tone audiometry and speech discrimination score. Auditory evaluations were performed before and 3 months after treatment using Siegel's criteria. The degree of improvement in four-tone average hearing and speech discrimination score was calculated from the results before and after treatment.
The total hearing improvement rate after the treatment was 75.0% (90/120 patients) in this study. Although 47 patients (78.3%) of coenzyme Q10 group showed better hearing improvement than 43 patients (71.7%) of control group, there was no significant difference. However, the coenzyme Q10 group showed significantly higher improvement in speech discrimination score.
From this study, we suggest that coenzyme Q10 may have beneficial effects in the treatment of sudden sensorineural hearing loss.

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Keywords

2 weeks
 
3 months
 
43 patients
 
5-day hospitalisation
 
Asan medical center
 
Auditory evaluations
 
auditory function
 
coenzyme Q10 group
 
control group
 
controlled prospective study
 
four-tone average hearing
 
hearing improvement
 
higher improvement
 
idiopathic sudden sensorineural hearing loss
 
pure tone audiometry
 
speech discrimination score
 
sudden sensorineural hearing loss
 
systemic steroid treatment
 
therapeutic efficacy
 
total hearing improvement rate