Future dentistry: cell therapy meets tooth and periodontal repair and regeneration
ABSTRACT Cell-based tissue repair of the tooth and - tooth-supporting - periodontal ligament (PDL) is a new attractive approach that complements traditional restorative or surgical techniques for replacement of injured or pathologically damaged tissues. In such therapeutic approaches, stem cells and/or progenitor cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we discuss the clonogenic potential of human dental and periodontal tissues such as the dental pulp and the PDL and their potential for tooth and periodontal repair and/or regeneration. We propose novel therapeutic approaches using stem cells or progenitor cells, which are targeted to regenerate the lost dental or periodontal tissue.
Full-textDOI: · Available from: Eumorphia Remboutsika, May 30, 2015
SourceAvailable from: Thimios A MitsiadisFrontiers in Physiology 03/2015; 6. DOI:10.3389/fphys.2015.00099
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ABSTRACT: Growth factors play critical roles in periodontal repair through the regulation of cell behavior. Many of the cell responses regulated by these proteins include cell adhesion, migration, proliferation and differentiation. Periodontal regeneration involves an organized response of different cells, tissues and growth factors implicated in the coordination of these events. However, periodontal tissue reconstruction is an extremely difficult task. Multiple studies have been performed to understand the specific role of growth factors in periodontal wound healing. In the present review we analyze the evidence that supports the roles of growth factors in periodontal wound healing and regeneration.Periodontology 2000 02/2015; 67(1). DOI:10.1111/prd.12068 · 3.00 Impact Factor
Article: Regenerated teeth: an updateRegenerative Medicine 01/2015; 10(1). · 3.50 Impact Factor