Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports

VA Boston Healthcare System , Boston, Massachusetts.
Photomedicine and laser surgery (Impact Factor: 1.67). 12/2010; 29(5):351-8. DOI: 10.1089/pho.2010.2814
Source: PubMed


Two chronic, traumatic brain injury (TBI) cases, where cognition improved following treatment with red and near-infrared light-emitting diodes (LEDs), applied transcranially to forehead and scalp areas, are presented.
Significant benefits have been reported following application of transcranial, low-level laser therapy (LLLT) to humans with acute stroke and mice with acute TBI. These are the first case reports documenting improved cognitive function in chronic, TBI patients treated with transcranial LED.
Treatments were applied bilaterally and to midline sagittal areas using LED cluster heads [2.1″ diameter, 61 diodes (9 × 633 nm, 52 × 870 nm); 12-15 mW per diode; total power: 500 mW; 22.2 mW/cm(2); 13.3 J/cm(2) at scalp (estimated 0.4 J/cm(2) to cortex)].
Seven years after closed-head TBI from a motor vehicle accident, Patient 1 began transcranial LED treatments. Pre-LED, her ability for sustained attention (computer work) lasted 20 min. After eight weekly LED treatments, her sustained attention time increased to 3 h. The patient performs nightly home treatments (5 years); if she stops treating for more than 2 weeks, she regresses. Patient 2 had a history of closed-head trauma (sports/military, and recent fall), and magnetic resonance imaging showed frontoparietal atrophy. Pre-LED, she was on medical disability for 5 months. After 4 months of nightly LED treatments at home, medical disability discontinued; she returned to working full-time as an executive consultant with an international technology consulting firm. Neuropsychological testing after 9 months of transcranial LED indicated significant improvement (+1, +2SD) in executive function (inhibition, inhibition accuracy) and memory, as well as reduction in post-traumatic stress disorder. If she stops treating for more than 1 week, she regresses. At the time of this report, both patients are continuing treatment.
Transcranial LED may improve cognition, reduce costs in TBI treatment, and be applied at home. Controlled studies are warranted.

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    • "Psychiatry Journal A report of two individual cases and a case series of eleven patients with TBI suggested that exposure to incoherent NIR and red light (870 nm/633 nm LEDs) positively affected sustained attention, memory and executive functions, and selfawareness , self-regulation, sleep, and depressed mood [14] [15]. These benefits in TBI patients were confirmed in a cohort of ten, treated with coherent NIR light (810 nm/980 nm laser) [16]. "
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    09/2015; 2015(2):352979. DOI:10.1155/2015/352979
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    • "A further example is the inflammatory genes involved in postoperative effusion by the increase in the anti-inflammatory transcription factor PPARYc [12]. SUMOylation and PPAR are interdependent in the transrepression of the inflammatory response [79] Antioxidant genes (MnSOD) are also up-regulated [6] as are DNA repair genes [80]. The role of laser effects and endogenous photons on gene transcription should be analysed in parallel [23] and Fig. 1 demonstrates how the three major signalling systems in the body can be integrated to encompass short term response of the organism through rapid neural response, through to medium and long term response, operating via neurotrophin, melanocortin and gene modulation processes. "
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    NAALT/WALT 2014 Conference; 09/2014
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    • "For example, low-energy infrared (803 nm) laser irradiation delivered to the epicardium was shown to reduce scar formation and myocardial infarct size several weeks after prolonged coronary artery occlusion in dogs and rats (Oron et al., 2001). Aside from the heart, the beneficial effects of NIR light treatment have been studied in particular in a model of traumatic brain injury as well as in wound healing (Ankri et al., 2010; Naeser et al., 2011). NIR light treatment also improved the collateral blood vessel grow in a mouse model (tight skin mouse) of scleroderma (Zaidi et al., 2013). "
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