Contribution of CNS cells in NeuroAIDS
ABSTRACT NeuroAIDS is becoming a major health problem among AIDS patients and long-term HIV survivors. As per 2009 estimates of UNAIDS report, more than 34 million people have been infected with HIV out of which ≥ 50% show signs and symptoms of neuropsychiatric disorders. These disorders affect central nervous system (CNS) and peripheral nervous systems (PNS). CNS is one of the most protected organ systems in body which is protected by blood-brain barrier (BBB). Not only this, most of the cells of CNS are negative for receptors and co-receptors for HIV infections. Neurons have been found to be completely nonpermissive for HIV infection. These facts suggest that neurotoxicity could be an indirect mechanism responsible for neuropsychiatric complications. In this review, we will discuss the importance of different cell types of CNS and their contribution toward neurotoxicity.
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Article: NEUROAIDS: A REAL CONCERN[Show abstract] [Hide abstract]
ABSTRACT: Improved antiretroviral treatments are still unable to cure HIV infections, therefore chronically lowlevels of HIV replication continues in patients. Long-term low replication of HIV leads toaccumulation of virotoxins, which could be a reason for neurotoxicity in long-term HIV survivors.Nowadays, more than 50% of HIV patients are presented with neuropsychiatric complications,known as NeuroAIDS. Increase in life-span of HIV seropositives, along with addition of newinfections every year is a real concern for NeuroAIDS as a new and emerging health problem.The IIOAB Journal. 01/2010;
- Current Perspectives in HIV Infection, 04/2013: chapter NeuroAIDS: Mechanisms, Causes, Prevalence, Diagnostics and Social Issues: pages 109-124; InTech.