Asymptomatic bacteriuria among HIV positive pregnant women

Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
Virulence (Impact Factor: 4.22). 05/2010; 1(3):130-3. DOI: 10.4161/viru.1.3.11384
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The prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. This prevalence might, even, be higher in patients with human immunodeficiency virus infection. Hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled HIV infected pregnant women attending PMTCT unit of Antiretroviral Clinic of University College Hospital, Ibadan, Nigeria between 1st May and 30th September 2007.Information was obtained on the socio-demographic characteristics of the subjects, CD4 count and viral load. Microbial culture was carried out on aseptically collected urines from the patients. Statistical analysis was done with SPSS 12 package. There were 161 analyzable samples from the participants. The mean age and gestational age at presentation of participants was 30.49 ± 4.3 years and 27.3 ± 3.2 weeks, respectively with modal parity of 2. Twenty-five (15.5%) of the urine samples significantly grew bacteria. The CD4 cells were significantly lower and the viral loads significantly higher(250.52 vs. 355.57 cells/mm3; 88,731 vs. 55,384 copies/ml; p = <0.0000) for the urine culture positive patients. Eshcherichia coli were isolated in 48%, Proteus in 16.0%, Klebsiella in 8.0% and Staphylococcus aureus in 28.0% of the urine positive cultures.The study showed that the prevalence of asymptomatic bacteriuria among PLWHAs is high. The microbial isolate from the urine samples were not different from those of HIV-negative patients.

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Available from: Olubukola Adesina, Oct 07, 2015
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    • "coli) [3] [4], Enterococcus species, Pseudomonas aeruginosa (P. aeruginosa), Klebsiella, Acinetobacter, Proteus species, Candida, and Salmonella species are also found among HIV infected patients [3] [4] [5]. As far as our knowledge to date is concerned, there is no published report on prevalence, etiologic agent, and the antimicrobial susceptibility pattern of bacterial uropathogens "
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    • "There are multiple opportunistic diseases found among HIV-infected pregnant women [39,40]. A study of this population at a large HIV treatment center in Lagos, Nigeria found that the most prevalent opportunistic diseases were oropharyngeal and vaginal candidiasis (24.0% of identified opportunistic disease cases), bacterial infections including pneumonia (12.9%), "
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    ABSTRACT: Abstract Objective: There are conflicting report on the association of HIV infection and asymptomatic bacteriuria (ASB). Most of these studies were from areas with low HIV burden. This study determined the prevalence and risk factors of ASB in HIV positive pregnant women. Methods: A cross sectional study among HIV positive pregnant women seen at a large PMTCT clinic in Lagos Nigeria. The women were evaluated for ASB at first clinic attendance. Blood samples were also collected for viral load, CD4 count and haemoglobin levels assessment. Data were managed with SPSS for windows version 19. Results: 102(18.1%) women out of 563 studied were found positive for asymptomatic bacteriuria. Ninety seven (95.1%) of the positive samples yielded single bacterial isolates. Escherichia.coli (44.3%) and Proteus mirabilis (21.6%) were the most common bacterial isolates. Previous urinary tract infection (OR:4.3), HIV-1 RNA greater than 10,000 copies/mL(OR:3.9), CD4 count< 200 cells/mm3 (OR:1.4) and maternal haemoglobin <11g/dl (OR: 1.4) were factors significantly associated with ASB after controlling for possible confounders. Conclusion: ASB is common in HIV positive pregnant women in our environment and is associated with previous UTI, high viral load, low CD4 count and maternal haemoglobin <11g/dl.
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