Obstructing giant post-inflammatory polyposis in ulcerative colitis: Case report and review of the literature
ABSTRACT Post-inflammatory polyps >15 mm in diameter or length are termed "giant". This benign and rare sequel of ulcerative colitis or colonic Crohn's disease can mimic colorectal carcinoma.
To illustrate this rare complication of inflammatory bowel disease and outline the characteristic radiological, endoscopic and histopathological features, by reviewing all previously published cases of giant post-inflammatory polyps in the English literature.
Reports of 81 giant post-inflammatory polyps in 78 patients were identified by systematic review of the literature. The incidence of giant post-inflammatory polyps is related to the extent of ulcerative colitis (incidence: 0%, 30%, and 70%, in proctitis, left-sided, and extensive disease, respectively). These lesions are typically located in the transverse or descending colon. Giant post-inflammatory polyps are as common in Crohn's disease (n=36) as in ulcerative colitis (n=42, 54%). Clinical presentations varies, including pain (n=29), rectal bleeding (n=20), diarrhoea (n=19), luminal obstruction (n=15), or a palpable mass (n=11). Symptomatic presentation results in surgical resection. Clinical details and outcomes are comprehensively tabulated.
Recognition of this rare entity will prevent unnecessary radical surgical resection for presumed carcinoma. It highlights the need for clinical, radiological, endoscopic and histopathological correlation.
Conference Paper: A 4Mb 0.18 mu m 1T1MTJ toggle MRAM memory[Show abstract] [Hide abstract]
ABSTRACT: The 4.5×6.3mm<sup>2</sup> 25ns cycle-time 4Mb Toggle MRAM memory, built in 0.18 μm 5M CMOS technology, uses a 1.55 μm<sup>2</sup> bit cell with a single toggling magneto tunnel junction. The memory uses uni-directional programming currents with isolated write and read paths and balanced current mirror sense amplifier.Solid-State Circuits Conference, 2004. Digest of Technical Papers. ISSCC. 2004 IEEE International; 03/2004
Article: An unusual complication of colitisGut 03/2010; 59(3):364, 415. DOI:10.1136/gut.2009.179689
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ABSTRACT: In the management of Crohn's disease, earlier aggressive treatment is becoming accepted as a strategy to prevent or retard progression to irreversible bowel damage. It is not yet clear, however, if this same concept should be applied to ulcerative colitis. Hence, we review herein the long-term structural and functional consequences of this latter disease. Disease progression in ulcerative colitis takes six principal forms: proximal extension, stricturing, pseudopolyposis, dysmotility, anorectal dysfunction, and impaired permeability. The precise incidence of these complications and the ability of earlier, more aggressive treatment to prevent them have yet to be determined.Inflammatory Bowel Diseases 01/2012; 18(7):1356-63. DOI:10.1002/ibd.22839