Vascular endothelial growth factor +936C/T and +405G/C polymorphisms and cancer risk: a meta-analysis.
ABSTRACT A number of investigators have studied the possible association between vascular endothelial growth factor (VEGF) polymorphisms and cancer risk, but the results have been conflicting. To examine the risk of cancer associated with the +936C/T and +405G/C polymorphisms of VEGF, all available studies were considered in the present meta-analysis.
We performed a computerized search of PubMed and Embase database for relevant studies. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.
Overall, the 936C allele showed no significant effect on cancer risk compared with the 936T allele in all subjects (OR = 0.77, 95% CI = 0.53-1.14; random model). Similarly, no significant effect of 405G allele compared with 405C on cancer risk was found (OR = 1.08, 95% CI = 0.94-1.24; random model). It indicated that the VEGF +936C/T and +405G/C polymorphisms might not be risk factors for cancer, but the 936C allele was associated with a decreased risk of oral cancer (OR = 0.72, 95% CI = 0.53-0.97; fixed model).
The evidence from our meta-analysis supports that there was an association between 936C allele and decreased oral cancer risk, although no evidence of association between VEGF +936C/T or +405G/C polymorphism and cancer was observed in all examined patients. Further studies based on larger, stratified population are required to explore the role of VEGF polymorphisms on cancer risk.
- Cytokine 01/1996; DOI:10.1109/CLEOE.1996.562529 · 2.87 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Associations between five polymorphisms of vascular endothelial growth factor (i.e., VEGF +936C/T, -1154A/G, -2578C/A, -634G/C and -460T/C) and risk of breast cancer have been extensively studied, and the currently available results are inconclusive. Therefore, we performed this meta-analysis to further study the associations. The databases of Pubmed, Embase and CNKI were retrieved up to April 1st, 2010. The pooled ORs and 95% CIs were used to assess the strength of the associations. A total of 10 case-control studies with 8175 cases and 8528 controls were included in this study. The overall results of combined analyses showed that five polymorphisms of VEGF were not associated with risk of breast cancer [ORs (95% CIs): 1.03 (0.84-1.27) for CC vs. TT for +936C/T, 0.95 (0.81-1.12) for AA vs. GG for -1154A/G, 1.01 (0.90-1.14) for CC vs. AA for -2578C/A, 1.02 (0.90-1.16) for GG vs. CC for -634G/C and 0.86 (0.68-1.09) for TT vs. CC for -460T/C]. When subgroup analyses by ethnicity for VEGF +936C/T and -634G/C, the results suggested that +936C/T was not associated with the risk of breast cancer for either Asians [1.40 (0.92-2.13) for CC vs. TT and CC+CT vs. TT: 1.38 (0.91-2.10) for CC+CT vs. TT] or Caucasians [0.93 (0.73-1.19) for CC vs. TT and 0.91 (0.72-1.16) for CC+CT vs. TT], and -634G/C was not associated with the breast cancer for Caucasians [1.07 (0.92-1.24) for GG vs. CC and 1.05 (0.91-1.21) for GG+GC vs. CC]. In addition, when excluding one study, which was out of Hardy-Weinberg equilibrium for VEGF +963C/T and whose controls were from both patients and healthy people, the negative results were also persistent, and ORs (95% CIs) were 1.04 (0.84-1.29) for CC vs. TT, 1.03 (0.83-1.27) for (CC+CT) vs. TT. This meta-analysis suggests that the VEGF +936C/T, -1154A/G, -2578C/A, -634G/C and -460T/C may be not associated with risk of breast cancer development based on the currently available studies, especially for Caucasians. More well designed studies with larger sample size on different ethnicities are needed to further assess the associations.Cytokine 07/2011; 56(2):167-73. DOI:10.1016/j.cyto.2011.06.018 · 2.87 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Colorectal cancer (CRC) constitutes one of the most common malignancies in the world and, despite advances in diagnostics and treatments, patients still face a poor prognosis and a more individualized treatment approach appears necessary. The VEGF system and angiogenesis are involved in many aspects of tumor biology and the efficacy of chemotherapy, and some targeted therapeutics appear to be related to the function of these processes. There are many reasons why genetic variations are optimal biomarkers and in relation to the VEGF system may prove to be of clinical relevance. This review evaluates the literature on SNPs in relation to the risk of CRC and the possible prognostic and predictive value and argues for the role of these biomarkers in the future treatment of patients with CRC.Pharmacogenomics 12/2011; 12(12):1681-93. DOI:10.2217/pgs.11.118 · 3.43 Impact Factor